Publications

Zhao S, Cordes J, Caban KM, Götz MJ, Mackens-Kiani T, Veltri AJ, Sinha NK, Weickert P, Kaya S, Hewitt G, Nedialkova DD, Fröhlich T, Beckmann R, Buskirk AR, Green R, Stingele J. RNF14-dependent atypical ubiquitylation promotes translation-coupled resolution of RNA-protein crosslinks. Mol Cell. 2023 Dec 7;83(23):4290-4303.e9. doi: 10.1016/j.molcel.2023.10.012. Epub 2023 Nov 10. PMID: 37951216. Link

Coller, J., Ignatova, Z. tRNA therapeutics for genetic diseases. Nat Rev Drug Discov (2023). https://doi.org/10.1038/s41573-023-00829-9
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Black JJ, Green R. Saving ribosomal proteins for later. Nat Cell Biol. 2023 Nov;25(11):1568-1569. doi: 10.1038/s41556-023-01251-4. PMID: 37845326. Link

Saba JA, Huang Z, Schole KL, Ye X, Bhatt SD, Li Y, Timp W, Cheng J, Green R. LARP1 senses free ribosomes to coordinate supply and demand of ribosomal proteins. bioRxiv [Preprint]. 2023 Nov 2:2023.11.01.565189. doi: 10.1101/2023.11.01.565189. PMID: 37961604; PMCID: PMC10635049. Link

Rattner A, Heng JS, Winer BL, Goff LA, Nathans J. Normal and Sjogren’s syndrome models of the murine lacrimal gland studied at single-cell resolution. Proc Natl Acad Sci U S A. 2023 Oct 17;120(42):e2311983120. doi: 10.1073/pnas.2311983120. Epub 2023 Oct 9. PMID: 37812717; PMCID: PMC10589653. Link

Nathans J. Seeing is believing: The development of optical coherence tomography. Proc Natl Acad Sci U S A. 2023 Sep 26;120(39):e2311129120. doi: 10.1073/pnas.2311129120. Epub 2023 Sep 21. PMID: 37732756; PMCID: PMC10523475. Link

Rattner A, Wang Y, Nathans J. Signaling Pathways in Neurovascular Development. Annu Rev Neurosci. 2022 Jul 8;45:87-108. doi: 10.1146/annurev-neuro-111020-102127. PMID: 35803586. Link

Livingston NM, Kwon J, Valera O, Saba JA, Sinha NK, Reddy P, Nelson B, Wolfe C, Ha T, Green R, Liu J, Wu B. Bursting translation on single mRNAs in live cells. Mol Cell. 2023 Jul 6;83(13):2276-2289.e11. doi: 10.1016/j.molcel.2023.05.019. Epub 2023 Jun 16. PMID: 37329884; PMCID: PMC10330622. Link

Wang J, Rattner A, Nathans J. Bacterial meningitis in the early postnatal mouse studied at single-cell resolution. Elife. 2023 Jun 15;12:e86130. doi: 10.7554/eLife.86130. PMID: 37318981; PMCID: PMC10270687. Link

Hsieh FL, Chang TH, Gabelli SB, Nathans J. Structure of WNT inhibitor adenomatosis polyposis coli down-regulated 1 (APCDD1), a cell-surface lipid-binding protein. Proc Natl Acad Sci U S A. 2023 May 16;120(20):e2217096120. doi: 10.1073/pnas.2217096120. Epub 2023 May 8. PMID: 37155902; PMCID: PMC10193966. Link

Park E, Mackens-Kiani T, Berhane R, Esser H, Erdenebat C, Burroughs AM, Berninghausen O, Aravind L, Beckmann R, Green R, Buskirk AR. B. subtilis MutS2 splits stalled ribosomes into subunits without mRNA cleavage. bioRxiv [Preprint]. 2023 May 6:2023.05.05.539626. doi: 10.1101/2023.05.05.539626. PMID: 37205477; PMCID: PMC10187299. Link

Chang TH, Hsieh FL, Gu X, Smallwood PM, Kavran JM, Gabelli SB, Nathans J. Structural insights into plasmalemma vesicle-associated protein (PLVAP): Implications for vascular endothelial diaphragms and fenestrae. Proc Natl Acad Sci U S A. 2023 Apr 4;120(14):e2221103120. doi: 10.1073/pnas.2221103120. Epub 2023 Mar 30. PMID: 36996108; PMCID: PMC10083539. Link

Koller TO, Scheid U, Kösel T, Herrmann J, Krug D, Boshoff HIM, Beckert B, Evans JC, Schlemmer J, Sloan B, Weiner DM, Via LE, Moosa A, Ioerger TR, Graf M, Zinshteyn B, Abdelshahid M, Nguyen F, Arenz S, Gille F, Siebke M, Seedorf T, Plettenburg O, Green R, Warnke AL, Ullrich J, Warrass R, Barry CE 3rd, Warner DF, Mizrahi V, Kirschning A, Wilson DN, Müller R. The Myxobacterial Antibiotic Myxovalargin: Biosynthesis, Structural Revision, Total Synthesis, and Molecular Characterization of Ribosomal Inhibition. J Am Chem Soc. 2023 Jan 18;145(2):851-863. doi: 10.1021/jacs.2c08816. Epub 2023 Jan 5. PMID: 36603206; PMCID: PMC9853869. Link

Martin, S., Allan, K.C., Pinkard, O. et al. Oligodendrocyte differentiation alters tRNA modifications and codon optimality-mediated mRNA decay. Nat Commun 13, 5003 (2022). https://doi.org/10.1038/s41467-022-32766-3
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John Paul Tsu Ouyang, Wenyan Lucy Zhang and Geraldine Seydoux. The conserved helicase ZNFX-1 memorializes silenced RNAs in perinuclear condensates. Nature Cell Biology, 2022.
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Torkzaban B, Kawalerski R, Coller J. Development of a Tethered mRNA Amplifier to increase protein expression. Biotechnol J. 2022 Oct;17(10):e2200214. doi: 10.1002/biot.202200214. Epub 2022 Jul 11. PMID: 35785475.
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Wang Y, Venkatesh A, Xu J, Xu M, Williams J, Smallwood PM, James A, Nathans J. The WNT7A/WNT7B/GPR124/RECK signaling module plays an essential role in mammalian limb development. Development. 2022 May 1;149(9):dev200340. doi: 10.1242/dev.200340. Epub 2022 May 12. Link

Saito K, Kratzat H, Campbell A, Buschauer R, Burroughs AM, Berninghausen O, Aravind L, Green R, Beckmann R, Buskirk AR. Ribosome collisions induce mRNA cleavage and ribosome rescue in bacteria. Nature. 2022 Mar;603(7901):503-508. doi: 10.1038/s41586-022-04416-7. Epub 2022 Mar 9. Link

Poyton MF, Feng XA, Ranjan A, Lei Q, Wang F, Zarb JS, Louder RK, Park G, Jo MH, Ye J, Liu S, Ha T, Wu C. Coordinated DNA and histone dynamics drive accurate histone H2A.Z exchange. Sci Adv. 2022 Mar 11;8(10):eabj5509. doi: 10.1126/sciadv.abj5509. Epub 2022 Mar 9. Link

Saguez C, Viterbo D, Descorps-Declère S, Cormack BP, Dujon B, Richard GF. Functional variability in adhesion and flocculation of yeast megasatellite genes. Genetics. 2022 May 5;221(1):iyac042. doi: 10.1093/genetics/iyac042. Link

Ivanov IP, Saba JA, Fan CM, Wang J, Firth AE, Cao C, Green R, Dever TE. Evolutionarily conserved inhibitory uORFs sensitize Hox mRNA translation to start codon selection stringency. Proc Natl Acad Sci U S A. 2022 Mar 1;119(9):e2117226119. doi: 10.1073/pnas.2117226119. Link

Bae H, Coller J. Codon optimality-mediated mRNA degradation: Linking translational elongation to mRNA stability. Mol Cell. 2022 Apr 21;82(8):1467-1476. doi: 10.1016/j.molcel.2022.03.032. PMID: 35452615; PMCID: PMC10111967.

Roger S Zou, Momcilo Gavrilov, Yang Liu , Dominique Rasoloson, Madison Conte, Justin Hardick, Leo Shen , Siqi Chen, Andrew Pekosz, Geraldine Seydoux, Yukari C Manabe, Taekjip Ha. Improving the specificity of nucleic acid detection with endonuclease-actuated degradation. Commun Biol. 2022 Mar 31;5(1):290.doi: 10.1038/s42003-022-03242-x. [Link]

Pascal Maguin, Andrew Varble, Joshua W Modell, Luciano A Marraffini. Cleavage of viral DNA by restriction endonucleases stimulates the type II CRISPR-Cas immune response. Mol Cell. 2022 Mar 3;82(5):907-919.e7.doi: 10.1016/j.molcel.2022.01.012. Epub 2022 Feb 7.[Link]

Laura Thomas, Geraldine Seydoux. Sperm granules mediate epigenetic inheritance. Nat Cell Biol. 2022 Feb;24(2):129-130.doi: 10.1038/s41556-021-00832-5. [Link]

Thomas L, Seydoux G. Sperm granules mediate epigenetic inheritance. Nat Cell Biol. 2022 Feb;24(2):129-130. doi: 10.1038/s41556-021-00832-5. No abstract available.
[Link]

LaForce GR, Farr JS, Liu J, Akesson C, Gumus E, Pinkard O, Miranda HC, Johnson K, Sweet TJ, Ji P, Lin A, Coller J, Philippidou P, Wagner EJ, Schaffer AE. Suppression of premature transcription termination leads to reduced mRNA isoform diversity and neurodegeneration. Neuron. 2022 Feb 4:S0896-6273(22)00057-5. doi: 10.1016/j.neuron.2022.01.018. Online ahead of print.
[Link]

Ouyang JPT, Seydoux G. RNA. Nuage condensates: accelerators or circuit breakers for sRNA silencing pathways?
2022 Jan;28(1):58-66. doi: 10.1261/rna.079003.121. Epub 2021 Nov 12. Review.
[Link]

Phan TP, Holland AJ. Time is of the essence: the molecular mechanisms of primary microcephaly. Genes Dev. 2021 Dec 1;35(23-24):1551-1578. doi: 10.1101/gad.348866.121. Review.
[Link]

Phan, T., Maryniak, A.L., Boatwright, C.A., Lee, J., Atkina, A., Tijhuis, A., Spierings, D.C.J., Bazzi, H., Foijer, F., Jordan, P.W., Stracker, T.H., and Holland, A.J. Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer. EMBO J 40(1) (2021).

Zhong Y Yeow Bramwell G LambrusRebecca MarlowKevin H ZhanMary-Anne DurinLauren T Evans Phillip M ScottThao PhanElizabeth ParkLorena A RuizDaniela MoralliEleanor G KnightLuned M BadderDaniela Novo,  Syed HaiderCatherine M GreenAndrew N J TuttChristopher J LordJ Ross ChapmanAndrew J Holland. Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer. Nature 2020  Sep;585(7825):447-452. doi: 10.1038/s41586-020-2690-1. Epub 2020 Sep 9. [Link]

Evans LT, Anglen T, Scott P, Lukasik K, Loncarek J, Holland AJ. ANKRD26 recruits PIDD1 to centriolar distal appendages to activate the PIDDosome following centrosome amplification. EMBO J. 2021 Feb 15;40(4):e105106. doi: 10.15252/embj.2020105106. Epub 2020 Dec 22.PMID: 33350495. [Link]

James A Saba, Kifayathullah Liakath-Ali, Rachel Green, Fiona M Watt. Review:Translational control of stem cell function. Nat Rev Mol Cell Biol. 2021 Oct;22(10):671-690. doi: 10.1038/s41580-021-00386-2. Epub 2021 Jul 16.
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Andrés Domínguez-Calvo, Pierre Gönczy, Andrew J Holland, Fernando R Balestra. TRIM37: a critical orchestrator of centrosome function. Cell Cycle 2021 Oct 21;1-9. doi: 10.1080/15384101.2021.1988289. Online ahead of print.
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Boris Zinshteyn, Niladri K Sinha, Syed Usman Enam, Benjamin Koleske, Rachel Green. Translational repression of NMD targets by GIGYF2 and EIF4E2. PLoS Genet 2021 Oct 19;17(10):e1009813.
doi: 10.1371/journal.pgen.1009813. eCollection 2021 Oct.
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Lori A Passmore, Jeff Coller. Review: Roles of mRNA poly(A) tails in regulation of eukaryotic gene expression. Nat Rev Mol Cell Biol. 2021 Sep 30. doi: 10.1038/s41580-021-00417-y. Online ahead of print.
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Andrew W Folkmann, Andrea Putnam, Chiu Fan Lee, Geraldine Seydoux. Regulation of biomolecular condensates by interfacial protein clusters. Science 2021 Sep 10;373(6560):1218-1224. doi: 10.1126/science.abg7071. Epub 2021 Sep 9. [Link]

Amer A Hossain 1 , Jon McGinn 1 , Alexander J Meeske 1 , Joshua W Modell 2 , Luciano A Marraffini. Viral recombination systems limit CRISPR-Cas targeting through the generation of escape mutations. Cell Host Microbe. 2021 Sep 22;S1931-3128(21)00417-0. doi: 10.1016/j.chom.2021.09.001. Online ahead of print. [Link]

Jeronimo C, Angel A, Nguyen VQ, Kim JM, Poitras C, Lambert E, Collin P, Mellor J, Wu C, Robert F. FACT is recruited to the +1 nucleosome of transcribed genes and spreads in a Chd1-dependent manner. Mol Cell. 2021 Aug 5:S1097-2765(21)00579-7. doi: 10.1016/j.molcel.2021.07.010. Epub ahead of print. PMID: 34380014.
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Nguyen VQ, Ranjan A, Liu S, Tang X, Ling YH, Wisniewski J, Mizuguchi G, Li KY, Jou V, Zheng Q, Lavis LD, Lionnet T, Wu C. Spatiotemporal coordination of transcription preinitiation complex assembly in live cells. Mol Cell. 2021 Aug 2:S1097-2765(21)00591-8. doi: 10.1016/j.molcel.2021.07.022. Epub ahead of print. PMID: 34375585.
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Kim JM, Visanpattanasin P, Jou V, Liu S, Tang X, Zheng Q, Li KY, Snedeker J, Lavis LD, Lionnet T, Wu C. Single-molecule imaging of chromatin remodelers reveals role of ATPase in promoting fast kinetics of target search and dissociation from chromatin. Elife. 2021 Jul 27;10:e69387. doi: 10.7554/eLife.69387. PMID: 34313223; PMCID: PMC8352589.
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Calderón L, Schindler K, Malin SG, Schebesta A, Sun Q, Schwickert T, Alberti C, Fischer M, Jaritz M, Tagoh H, Ebert A, Minnich M, Liston A, Cochella L, Busslinger M. Pax5 regulates B cell immunity by promoting PI3K signaling via PTEN down-regulation. Sci Immunol. 2021 Jul 23;6(61):eabg5003. doi: 10.1126/sciimmunol.abg5003. PMID: 34301800; PMCID: PMC7611449.
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Schmidt H, Putnam A, Rasoloson D, Seydoux G. Protein-based condensation mechanisms drive the assembly of RNA-rich P granules. Elife. 2021 Jun 9;10:e63698. doi: 10.7554/eLife.63698. PMID: 34106046; PMCID: PMC8238508. Link

Wang Q, Hernández-Ochoa EO, Viswanathan MC, Blum ID, Do DC, Granger JM, Murphy KR, Wei AC, Aja S, Liu N, Antonescu CM, Florea LD, Talbot CC Jr, Mohr D, Wagner KR, Regot S, Lovering RM, Gao P, Bianchet MA, Wu MN, Cammarato A, Schneider MF, Bever GS, Anderson ME. CaMKII oxidation is a critical performance/disease trade-off acquired at the dawn of vertebrate evolution. Nat Commun. 2021 May 26;12(1):3175. doi: 10.1038/s41467-021-23549-3. PMID: 34039988; PMCID: PMC8155201. Link

Shubin CB, Mayangsari R, Swett AD, Greider CW. Rif1 regulates telomere length through conserved HEAT repeats. Nucleic Acids Res. 2021 Apr 19;49(7):3967-3980. doi: 10.1093/nar/gkab206. PMID: 33772576; PMCID: PMC8053089. Link

Pokrass MJ, Regot S. 3D time-lapse microscopy paired with endpoint lineage analysis in mouse blastocysts. STAR Protoc. 2021 Apr 8;2(2):100446. doi: 10.1016/j.xpro.2021.100446. PMID: 33899025; PMCID: PMC8055709. Link

Clark HR, McKenney C, Livingston NM, Gershman A, Sajjan S, Chan IS, Ewald AJ, Timp W, Wu B, Singh A, Regot S. Epigenetically regulated digital signaling defines epithelial innate immunity at the tissue level. Nat Commun. 2021 Mar
23;12(1):1836. doi: 10.1038/s41467-021-22070-x. PMID: 33758175; PMCID: PMC7988009. Link

Guan R, Lian T, Zhou BR, He E, Wu C, Singleton M, Bai Y. Structural and dynamic mechanisms of CBF3-guided centromeric nucleosome formation. Nat Commun. 2021 Mar 19;12(1):1763. doi: 10.1038/s41467-021-21985-9. PMID: 33741944; PMCID: PMC7979930. Link

Xu Z, Green B, Benoit N, Sobel JD, Schatz MC, Wheelan S, Cormack BP. Cell wall protein variation, break-induced replication, and subtelomere dynamics in Candida glabrata. Mol Microbiol. 2021 Mar 13. doi: 10.1111/mmi.14707. Epub  ahead of print. PMID: 33713372. Link

Gutiérrez-Pérez, P., Santillán, E.M., Lendl, T., Schrempf, A., Steinacker, T.L., Asparuhova, M., Brandstetter, M., Haselbach, D. and Cochella, L. miR-1 sustains muscle physiology by controlling V-ATPase complex assembly. In press at Science Advances. (Previously on bioRxiv: https://doi.org/10.1101/2020.08.31.275644)

Dexheimer, P.J., Wang, J. and Cochella, L. Two miRNAs are sufficient for embryonic patterning in C. elegans. Curr. Biol. 2020; S0960-9822(20)31436-6. doi: 10.1016/j.cub.2020.09.066. Link

Ketting RF & Cochella L. Concepts and functions of small RNA pathways in C. elegans. Curr. Top. Dev. Biol. 2020. https://doi.org/10.1016/bs.ctdb.2020.08.002. Link

Charest, J., Daniele, T., Wang, J., Bykov, A., Mandlbauer, A., Asparuhova, M., Röhsner, J., Gutiérrez-Pérez, P. and Cochella, L. Combinatorial action of temporally segregated transcription factors. Dev. Cell. 2020;55(4),483-499. Link

Dexheimer P & Cochella L. MicroRNAs: from mechanism to organism. Front. Cell Dev. Biol. 2020; 8,409. doi: 10.3389/fcell.2020.00409. eCollection 2020. Link

Alberti C, Manzenreither RA, Sowemimo I, Burkard TR, Wang J, Mahofsky K, Ameres SL* & Cochella L*. Cell-type specific sequencing of microRNAs from complex animal tissues. Nat Meth. 2018;15,283–289. *Co-corresponding authors. Link

Alberti C & Cochella L. A framework for understanding the roles of miRNAs in animal development. Development. 2017;144,2548–2559. Link

Drexel T, Mahofsky K, Latham R, Zimmer M & Cochella L. Neuron type-specific miRNA represses two broadly expressed genes to modulate an avoidance behavior in C. elegans. Genes & Development. 2016;30,2042–2047. Link

Workman RE, Pammi T, Nguyen BTK, Graeff LW, Smith E, Sebald SM, Stoltzfus MJ, Euler CW, Modell JW. (2021) A natural single guide RNA repurposes Cas9 to autoregulate CRISPR-Cas expression. Cell. 2021 Jan 6:S0092-8674(20)31687-1. doi: 10.1016/j.cell.2020.12.017. Epub ahead of print. PMID: 33421369. [link] [pdf]
Pokrass MJ, Ryan KA, Xin T, Pielstick B, Timp W, Greco V, Regot S. Cell Cycle Dependent ERK Signaling Dynamics Directs Fate Specification in the Mammalian Preimplantation Embryo. (2020) Developmental Cell. [link] [pdf]

Aikin T, Peterson A, Pokrass MJ, Clark HR, Regot S. MAPK Activity Dynamics Regulates Non-Cell Autonomous Effects of Oncogene Expression. (2020) Elife. Sep 17;9:e60541. [link] [pdf]

Rattner A, Terrillion CE, Jou C, Kleven T, Hu SF, Williams J, Hou Z, Aggarwal M, Mori S, Shin G, Goff LA, Witter MP, Pletnikov M, Fenton AA, Nathans J. (2020) Developmental, cellular, and behavioral phenotypes in a mouse model of congenital hypoplasia of the dentate gyrus. Elife. 9:e62766. doi: 10.7554/eLife.62766. PMID: 33084572 [link]

Pinkard O, McFarland S, Sweet T, Coller J. Quantitative tRNA-sequencing uncovers metazoan tissue-specific tRNA regulation. Nature Communications. 2020;11(1):4104. Published 2020 Aug 14. doi:10.1038/s41467-020-17879-x [link]

Schaffer, AE, Pinkard, O., and Coller J (2019). tRNA Metabolism and Neurodevelopmental Disorders. Annual Reviews Genomics Human Genetics. PMID 31082281. [ link ] [ pdf ]

Chang TH, Hsieh FL, Smallwood PM, Gabelli SB, Nathans J. (2020) Structure of the RECK CC domain, an evolutionary anomaly. Proceedings of the National Academy of Sciences of the United States of America.117(26):15104-15111. doi: 10.1073/pnas.2006332117. Epub 2020 Jun 15. PMID: 32541044 [link]

Wang Y, Smallwood PM, Williams J, Nathans J. (2020) A mouse model for kinesin family member 11 (Kif11)-associated familial exudative vitreoretinopathy. Human Molecular Genetics. (7):1121-1131. doi: 10.1093/hmg/ddaa018. PMID: 31993640 [link]

Lee, CY, Putnam, A, Lu T, He S, Ouyang JPT and Seydoux, G. Recruitment of mRNAs to P granules by condensation with intrinsically disordered proteins. Elife. 2020 Jan 24;9:e52896. doi: 10.7554/eLife.52896. [link]

Sabbagh M.F., Nathans J. (2020) A genome-wide view of the de-differentiation of central nervous system endothelial cells in culture. eLife 9:e51276 doi: 10.7554/eLife.51276. [ link ] [ pdf ]

Park, E, Scott, PM, Clutario, KM, Cassidy, KB, Zhan, K, Gerber and Holland, AJ. (2019) WBP11 is required for splicing the TUBGCP6 pre-mRNA to promote centriole duplication. Journal of Cell Biology 219 (1): e201904203. [ link ] [ pdf ]

Mercey, O*, Levine, M.S*, LoMastro, G, Rostaing, P, Brotslaw, E, Gomez, V, Kumar, A, Spassky, N, Mitchell, BJ, Meunier, A* and Holland, AJ.* (2019) Massive centriole production can occur in the absence of deuterosomes in multiciliated cells. Nature Cell Biology 21: 1544-52. (2019). *equal contribution [ link ] [ pdf ]

Alexandre Paix, Dominique Rasoloson, Andrew Folkmann, and Geraldine Seydoux (2019). Rapid Tagging of Human Proteins with Fluorescent Reporters by Genome Engineering using Double-Stranded DNA Donors. Current Protocols in Molecular Biology e102, Volume 129. [ link ]

Heng J.S., Hackett S.F., Stein-O’Brien G.L., Winer B.L., Williams J., Goff L.A., Nathans J. (2019) Comprehensive analysis of a mouse model of spontaneous uveoretinitis using single-cell RNA sequencing. Proceedings of the National Academy of Sciences of the United States of America 116 (52) 26734-26744. [ link ] [ pdf ]

Lee CY, Putnam A, Lu T, Seydoux G. (2019) Recruitment of mRNAs to P granules by gelation with intrinsically-disordered proteins. http://biorxiv.org/cgi/content/short/732057v1. [ pdf ]

Ouyang, JPT, Folkmann, A, Bernard, L, Lee, CY, Seroussi, U, Charlesworth, AG et al. P Granules Protect RNA Interference Genes from Silencing by piRNAs. Dev. Cell. 2019</u>; :. doi: 10.1016/j.devcel.2019.07.026. [ pdf ]

Cable, J, Brangwynne, C, Seydoux, G, Cowburn, D, Pappu, RV, Castañeda, CA et al. Phase separation in biology and disease-a symposium report. Ann. N. Y. Acad. Sci. 2019;1452 (1):3-11. doi: 10.1111/nyas.14126. [ pdf ]

Putnam, A, Cassani, M, Smith, J, Seydoux, G. A gel phase promotes condensation of liquid P granules in Caenorhabditis elegans embryos. Nat. Struct. Mol. Biol. 2019;26 (3):220-226. doi: 10.1038/s41594-019-0193-2. [ pdf ]

Folkmann, AW, Seydoux, G. Spatial regulation of the polarity kinase PAR-1 by parallel inhibitory mechanisms. Development. 2019;146 (6):. doi: 10.1242/dev.171116. [ pdf ]

Lee, CY, Seydoux, G. Dynamics of mRNA entry into stress granules. Nat. Cell Biol. 2019;21 (2):116-117. doi: 10.1038/s41556-019-0278-5. [ pdf ]

Paix A, Rasoloson D, Folkman A, Seydoux G. (2019) Rapid Tagging of Human Proteins with Fluorescent Reporters by Genome Engineering using Double‐Stranded DNA Donors. Current Protocols in Molecular Biology Volume 129, e102. doi: 10.1002/cpmb.102 [ link ]

Rattner A., Williams J., Nathans J. (2019) Roles of HIFs and VEGF in angiogenesis in the retina and brain. The Journal of Clinical Investigation 129 (9):3807-3820. [ link ] [ pdf ]

Pike AM, Strong MA, Ouyang JPT, Greider CW. (2019) TIN2 functions with TPP1/POT1 to stimulate telomerase processivity. American Society for Microbiology ASM:doi: https://doi.org/10.1128/MCB.00593-18[ link ] [ pdf ]

Peng X, Williams J, Smallwood PM, Nathans J. (2019) Defining the binding interface of Amyloid Precursor Protein (APP) and Contactin3 (CNTN3) by site-directed mutagenesis. PLoS ONE 14(7):e0219384. [ link ] [ pdf ]

Cho, C., Wang, Y., Smallwood, P.M., Williams, J., Nathans, J. (2019) Molecular determinants in Frizzled, Reck, and Wnt7a for ligand-specific signaling in neurovascular development.  eLife 8: e47300. [ pdf ]

D’Orazio KN, Wu CC, Sinha NK, Loll-Krippleber R, Brown GW, Green R. (2019) The endonuclease Cue2 cleaves mRNAs at stalled ribosomes during No Go Decay. eLife 2019;8:e49117 doi: 10.7554/eLife.49117 [ link ] [ pdf ]

Kearse MG, Goldman DH, Choi J, Nwaezeapu C, Liang D, Green KM, Goldstrohm AC, Todd PK, Green R, Wilusz JE. (2019) Ribosome queuing enables non-AUG translation to be resistant to multiple protein synthesis inhibitors. Genes and Development 33: 871-885. [ link ] [ pdf ]

Moyer TC, Holland AJ. (2019) PLK4 promotes centriole duplication by phosphorylating STIL to link the procentriole to the microtubule wall. eLife 8: e46054. [ link ] [ pdf ]

 

Cho C., Wang Y., Smallwood P.M., Williams J., Nathans J. (2019) Dlg1 activates beta-catenin signaling to regulate retinal angiogenesis and the blood-retina and blood-brain barriers. eLife 2019;8:e45542 doi: 10.7554/eLife.45542. [ link ] [ pdf ]

LoMastro GM, Holland AJ. (2019) The emerging link between centrosome aberrations and metastasis. Developmental Cell 49(3): 325-31. (2019). [ link ] [ pdf ]

DeFelice MM, Clark HR, Hughey JJ, Maayan I, Kudo T, Gutschow MV, Covert MW, Regot S. (2019) NF-κB signaling dynamics is controlled by a dose-sensing autoregulatory loop. Science Signaling. 12(579). pii: eaau3568. doi: 10.1126/scisignal.aau3568. [ link ] [ pdf ]

Wang, Y, Sabbagh, MF,  Gu, X, Rattner, A, Williams, J, and Nathans, J. (2019) Beta-catenin signaling regu lates barrier-specific gene expression in circumventricular organ and ocular vasculatures.  eLife 8: e43257. [ pdf ]

Heng, J.S., Rattner, A., Stein-O’Brien, G.L., Winer, B.L., Jones, B.W., Vernon, H.J., Goff, L.A., and Nathans, J . (2019)  Hypoxia tolerance in the Norrin-deficient retina and the chronically hypoxic brain studied at single-cell resolution. Proceedings of the National Academy of Sciences USA  116:9103-9114. [ pdf ]

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