A listing of publications from the last 12 months...

2020

Sabbagh M.F., Nathans J. (2020) A genome-wide view of the de-differentiation of central nervous system endothelial cells in culture. eLife 9:e51276 doi: 10.7554/eLife.51276.  [ link ]
Putnam A, Cassani M, Smith J, Seydoux G. (2020) Author Correction: A gel phase promotes condensation of liquid P granules in Caenorhabditis elegans embryos. Nature Structural & Molecular Biology. doi: 10.1038/s41594-019-0367-y. PubMed PMID:31896770. [ link ]

2019

Park, E, Scott, PM, Clutario, KM, Cassidy, KB, Zhan, K, Gerber and Holland, AJ. (2019) WBP11 is required for splicing the TUBGCP6 pre-mRNA to promote centriole duplication. Journal of Cell Biology 219 (1): e201904203. [ link ]
Mercey, O*, Levine, M.S*, LoMastro, G, Rostaing, P, Brotslaw, E, Gomez, V, Kumar, A, Spassky, N, Mitchell, BJ, Meunier, A* and Holland, AJ.* (2019) Massive centriole production can occur in the absence of deuterosomes in multiciliated cells. Nature Cell Biology 21: 1544-52. (2019). *equal contribution [ link ]
Alexandre Paix, Dominique Rasoloson, Andrew Folkmann, and Geraldine Seydoux (2019). Rapid Tagging of Human Proteins with Fluorescent Reporters by Genome Engineering using Double-Stranded DNA Donors. Current Protocols in Molecular Biology e102, Volume 129. [ link ]
Heng J.S., Hackett S.F., Stein-O'Brien G.L., Winer B.L., Williams J., Goff L.A., Nathans J. (2019) Comprehensive analysis of a mouse model of spontaneous uveoretinitis using single-cell RNA sequencing. Proceedings of the National Academy of Sciences of the United States of America 116 (52) 26734-26744. [ link ]
Lee, CY, Putnam, A, Lu T., Seydoux, G 2019. Recruitment of mRNAs to P granules by gelation with intrinsically-disordered proteins. http://biorxiv.org/cgi/content/short/732057v1.
Ouyang, JPT, Folkmann, A, Bernard, L, Lee, CY, Seroussi, U, Charlesworth, AG et al. P Granules Protect RNA Interference Genes from Silencing by piRNAs. Dev. Cell. 2019; :. doi: 10.1016/j.devcel.2019.07.026.
Cable, J, Brangwynne, C, Seydoux, G, Cowburn, D, Pappu, RV, Castañeda, CA et al. Phase separation in biology and disease-a symposium report. Ann. N. Y. Acad. Sci. 2019;1452 (1):3-11. doi: 10.1111/nyas.14126.
Putnam, A, Cassani, M, Smith, J, Seydoux, G. A gel phase promotes condensation of liquid P granules in Caenorhabditis elegans embryos. Nat. Struct. Mol. Biol. 2019;26 (3):220-226. doi: 10.1038/s41594-019-0193-2.
Folkmann, AW, Seydoux, G. Spatial regulation of the polarity kinase PAR-1 by parallel inhibitory mechanisms. Development. 2019;146 (6):. doi: 10.1242/dev.171116. 
Lee, CY, Seydoux, G. Dynamics of mRNA entry into stress granules. Nat. Cell Biol. 2019;21 (2):116-117. doi: 10.1038/s41556-019-0278-5.
Paix A, Rasoloson D, Folkman A, Seydoux G. (2019) Rapid Tagging of Human Proteins with Fluorescent Reporters by Genome Engineering using Double‐Stranded DNA Donors. Current Protocols in Molecular Biology Volume 129, e102. doi: 10.1002/cpmb.102 [ link ]
Rattner A., Williams J., Nathans J. (2019) Roles of HIFs and VEGF in angiogenesis in the retina and brain. The Journal of Clinical Investigation 129 (9):3807-3820. [ link ]
Pike AM, Strong MA, Ouyang JPT, Greider CW. (2019) TIN2 functions with TPP1/POT1 to stimulate telomerase processivity. American Society for Microbiology ASM:doi: https://doi.org/10.1128/MCB.00593-18. [ link ]
Peng X, Williams J, Smallwood PM, Nathans J. (2019) Defining the binding interface of Amyloid Precursor Protein (APP) and Contactin3 (CNTN3) by site-directed mutagenesis. PLoS ONE 14(7):e0219384. [ link ]
Cho, C., Wang, Y., Smallwood, P.M., Williams, J., Nathans, J. (2019) Molecular determinants in Frizzled, Reck, and Wnt7a for ligand-specific signaling in neurovascular development.  eLife 8: e47300.
D'Orazio KN, Wu CC, Sinha NK, Loll-Krippleber R, Brown GW, Green R. (2019) The endonuclease Cue2 cleaves mRNAs at stalled ribosomes during No Go Decay. eLife 2019;8:e49117 doi: 10.7554/eLife.49117 [ link ]
Kearse MG, Goldman DH, Choi J, Nwaezeapu C, Liang D, Green KM, Goldstrohm AC, Todd PK, Green R, Wilusz JE. (2019) Ribosome queuing enables non-AUG translation to be resistant to multiple protein synthesis inhibitors. Genes and Development 33: 871-885. [ link ]
Moyer TC, Holland AJ. (2019) PLK4 promotes centriole duplication by phosphorylating STIL to link the procentriole to the microtubule wall. eLife 8: e46054.  [ link ]
Cho C., Wang Y., Smallwood P.M., Williams J., Nathans J. (2019) Dlg1 activates beta-catenin signaling to regulate retinal angiogenesis and the blood-retina and blood-brain barriers. eLife 2019;8:e45542 doi: 10.7554/eLife.45542. [ link ]
LoMastro GM, Holland AJ. (2019) The emerging link between centrosome aberrations and metastasis. Developmental Cell 49(3): 325-31. (2019). [ link ]
DeFelice MM, Clark HR, Hughey JJ, Maayan I, Kudo T, Gutschow MV, Covert MW, Regot S. (2019) NF-κB signaling dynamics is controlled by a dose-sensing autoregulatory loop. Science Signaling. 12(579). pii: eaau3568. doi: 10.1126/scisignal.aau3568.   [ link ]
Wang, Y, Sabbagh, MF,  Gu, X, Rattner, A, Williams, J, and Nathans, J. (2019) Beta-catenin signaling regu lates barrier-specific gene expression in circumventricular organ and ocular vasculatures.  eLife 8: e43257.
Heng, J.S., Rattner, A., Stein-O’Brien, G.L., Winer, B.L., Jones, B.W., Vernon, H.J., Goff, L.A., and Nathans, J . (2019)  Hypoxia tolerance in the Norrin-deficient retina and the chronically hypoxic brain studied at single-cell resolution. Proceedings of the National Academy of Sciences USA  116:9103-9114.