Nancy L. Craig
Professor Emerita Our work is focused on the molecular mechanisms by which transposable elements move and how they can be exploited for genome engineering. These elements are discrete pieces of DNA that can move between many different insertion sites. They are present in virtually all…
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Se-Jin Lee
Professor Emeritus
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Stephen Desiderio
Professor Emeritus The laboratory is interested in molecular and genetic mechanisms responsible for development of the immune system. The generation of immunologic diversity provides a spectacular example of genomic plasticity in the form of V(D)J recombination. This process, which builds antigen receptor genes from discrete…
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Carol Greider
Telomeres protect chromosome ends from being recognized as DNA damage and chromosomal rearrangements. Conventional replication leads to telomere shortening, but telomere length is maintained by the enzyme telomerase that synthesizes telomere sequences de novo onto chromosome ends. Telomerase is specialized reverse transcriptase, requiring both a…
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Randall Reed
The mammalian olfactory system provides an excellent model to study two of the important questions in molecular neurobiology. The continual replacement of olfactory receptor neurons mimics many aspects of neuronal differentiation and development in the brain. The olfactory system, therefore, provides a unique opportunity to…
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Thomas Kelly
Professor Emeritus
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Hamilton Smith
Hamilton O. Smith received an A.B. degree in mathematics at the University of California, Berkeley in 1952 and the M.D. degree from Johns Hopkins University in 1956. After six years of clinical work in medicine (1956-1962), he carried out research on Salmonella phage P22 lysogeny…
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