Sofia Quinodoz
Research Description: Inside every human cell, six feet of DNA and thousands of RNAs and proteins are packed into a tiny nucleus. This raises the question: How is the cell able to execute various complex reactions like gene regulation, RNA splicing, and ribosome assembly in…
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Erin Goley
Research Description Bacteria are ubiquitous microorganisms that impact human health in myriad ways, including as pathogens and as commensal members of the microbiota. A fundamental understanding of the mechanisms of bacterial growth and adaptation is key to controlling their replication and survival. Our overarching research…
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Tamara O’Connor
The outcome of most parasitic relationships is decided by an elaborate series of events involving hundreds of proteins. Understanding this interaction requires the analysis of the molecular mechanisms operating in both organisms and the causal relationships acting at the interface between them. The O’Connor lab…
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Luisa Cochella
Transcriptional and Post-transcriptional Mechanisms for Cell Diversification. The evolution of multicellularity occurred hand in hand with the diversification of cell types with disparate morphologies and functions. This segregation of function across different cell types enabled astounding animal complexity; but at the same time, extreme specializations…
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Jeff Coller
Messenger RNA (mRNA) translation by the ribosome represents the final step on a complicated molecular dance from DNA to protein. Though classically considered a decipherer that translates our 64-word genetic code into a proteome of astonishing complexity, recent work has unexpectedly shown that the ribosome…
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Brendan Cormack
The Cormack lab is focused on the molecular understanding of Candida pathogenesis and virulence. We are finding new pathways involved in the relationship between Candida glabrata and the host, and are defining the evolutionary adaptations of Candida that permit it to so successfully colonize humans…
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Jeremy Nathans
Biology: Frizzled receptors in development and disease Our laboratory has focused for the past two decades on a large family of cell-surface receptors called Frizzled. This name refers to the appearance of fruit flies in which the receptor gene is mutated: the hairs and bristles…
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Sergi Regot
A fundamental property of living cells is their extraordinary ability to sense and respond to a changing environment. In higher eukaryotes, malfunctioning of signaling networks has many devastating consequences such as cancer, diabetes or autoimmunity. Such consequences arise from the inability of cells to properly…
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Geraldine Seydoux
Our lab studies the earliest stages of embryogenesis to understand how single-celled eggs develop into complex multicellular embryos. We focus on the choice between soma and germline, one of the first developmental decisions faced by embryos. Our goal is to identify and characterize the molecular…
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Rachel Green
The ribosome is a complex molecular machine that translates the genetic code into functional polypeptides. Our work focuses on understanding how the ribosome functions at a molecular level and how changes in its activity lead to mRNA quality control and the induction of cellular stress…
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