
John Williams
Research Technologist
jwilli67@jhmi.edu
(410) 955-4680
Publications
- Heng J.S., Hackett S.F., Stein-O'Brien G.L., Winer B.L., Williams J., Goff L.A., Nathans J. (2019) Comprehensive analysis of a mouse model of spontaneous uveoretinitis using single-cell RNA sequencing. Proceedings of the National Academy of Sciences of the United States of America 116 (52) 26734-26744. [ link ] [ pdf ]
- Rattner A., Williams J., Nathans J. (2019) Roles of HIFs and VEGF in angiogenesis in the retina and brain. The Journal of Clinical Investigation 129 (9):3807-3820. [ link ] [ pdf ]
- Peng X, Williams J, Smallwood PM, Nathans J. (2019) Defining the binding interface of Amyloid Precursor Protein (APP) and Contactin3 (CNTN3) by site-directed mutagenesis. PLoS ONE 14(7):e0219384. [ link ] [ pdf ]
- Cho, C., Wang, Y., Smallwood, P.M., Williams, J., Nathans, J. (2019) Molecular determinants in Frizzled, Reck, and Wnt7a for ligand-specific signaling in neurovascular development. eLife 8: e47300. [ pdf ]
- Cho C., Wang Y., Smallwood P.M., Williams J., Nathans J. (2019) Dlg1 activates beta-catenin signaling to regulate retinal angiogenesis and the blood-retina and blood-brain barriers. eLife 2019;8:e45542 doi: 10.7554/eLife.45542. [ link ] [ pdf ]
- Wang, Y, Sabbagh, MF, Gu, X, Rattner, A, Williams, J, and Nathans, J. (2019) Beta-catenin signaling regu lates barrier-specific gene expression in circumventricular organ and ocular vasculatures. eLife 8: e43257. [ pdf ]
- Wang, Y., Cho, C., Williams, J., Smallwood, P.M., Zhang, C., Junge, H.J., and Nathans, J. (2018) Interplay of the Norrin and Wnt7a/Wnt7b signaling systems in blood-brain barrier and blood-retina barrier development and maintenance. Proceedings of the National Academy of Sciences USA 15: E11827-E11836. [ pdf ]
- Chang, H., Smallwood, P.M., Williams, J., and Nathans, J. (2017) Intramembrane proteolysis of Astrotactins. Journal of Biological Chemistry 292: 3506-3516. [ pdf ]
- Wang, Y., Williams, J., Rattner, A., Wu, S., Bassuk, A.G., Goffinet, A.M., and Nathans, J. (2016) Patterning of papillae on the mouse tongue: A system for the quantitative assessment of planar cell polarity signaling. Developmental Biology 419: 298-310. [ pdf ]
- Chang, H., Smallwood, P.M., Williams, J., and Nathans, J. (2016) The spatio-temporal domains of Frizzled6 action in planar polarity control of hair follicle orientation. Developmental Biology 409: 181-193. [ pdf ]