Recent Publications

Phan, T., Maryniak, A.L., Boatwright, C.A., Lee, J., Atkina, A., Tijhuis, A., Spierings, D.C.J., Bazzi, H., Foijer, F., Jordan, P.W., Stracker, T.H., and Holland, A.J. Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer. EMBO J 40(1) (2021).

Zhong Y Yeow Bramwell G LambrusRebecca MarlowKevin H ZhanMary-Anne DurinLauren T Evans Phillip M ScottThao PhanElizabeth ParkLorena A RuizDaniela MoralliEleanor G KnightLuned M BadderDaniela Novo,  Syed HaiderCatherine M GreenAndrew N J TuttChristopher J LordJ Ross ChapmanAndrew J Holland. Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer. Nature 2020  Sep;585(7825):447-452. doi: 10.1038/s41586-020-2690-1. Epub 2020 Sep 9. [Link]

Evans LT, Anglen T, Scott P, Lukasik K, Loncarek J, Holland AJ. ANKRD26 recruits PIDD1 to centriolar distal appendages to activate the PIDDosome following centrosome amplification. EMBO J. 2021 Feb 15;40(4):e105106. doi: 10.15252/embj.2020105106. Epub 2020 Dec 22.PMID: 33350495. [Link]

James A Saba, Kifayathullah Liakath-Ali, Rachel Green, Fiona M Watt. Review:Translational control of stem cell function. Nat Rev Mol Cell Biol. 2021 Oct;22(10):671-690. doi: 10.1038/s41580-021-00386-2. Epub 2021 Jul 16.
Link

Andrés Domínguez-Calvo, Pierre Gönczy, Andrew J Holland, Fernando R Balestra. TRIM37: a critical orchestrator of centrosome function. Cell Cycle 2021 Oct 21;1-9. doi: 10.1080/15384101.2021.1988289. Online ahead of print.
Link

Boris Zinshteyn, Niladri K Sinha, Syed Usman Enam, Benjamin Koleske, Rachel Green. Translational repression of NMD targets by GIGYF2 and EIF4E2. PLoS Genet 2021 Oct 19;17(10):e1009813.
doi: 10.1371/journal.pgen.1009813. eCollection 2021 Oct.
Link

Lori A Passmore, Jeff Coller. Review: Roles of mRNA poly(A) tails in regulation of eukaryotic gene expression. Nat Rev Mol Cell Biol. 2021 Sep 30. doi: 10.1038/s41580-021-00417-y. Online ahead of print.
Link

Research

A natural single-guide RNA repurposes Cas9 to autoregulate CRISPR-Cas expression

Work by RE Workman and T Pammi from the Modell lab:

CRISPR-Cas systems provide their prokaryotic hosts with acquired immunity against viruses...

Multiplexed monitoring to track single cell signaling dynamics

We highlight the research of the Regot Lab:

 

A fundamental property of living cells is their extraordinary ability to sense and...

Scalable and versatile genome editing using linear DNAs with microhomology to Cas9 Sites in Caenorhabditis elegans

Work by Alex Paix from the Seydoux Lab:

"Homology-directed repair (HDR) of double-strand DNA breaks is a promising method for genome...