Department of Molecular Biology & Genetics

mailto:mbg@mbghopkins.org

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News

Apr 13

Northwestern University Awards 2022 Mechthild Esser Nemmers Prize in Medical Science to Jeremy Nathans, MD, PhD

Mar 08

This year’s Gruber Prize in Genetics has been awarded to Geraldine Seydoux, Ruth Lehman, and James Priess

Jan 29

Luisa Cochella, Ph.D receives the 2022 Elisa Izaurralde Award for Innovation in Research, Teaching, and Service

Oct 01

New! Alumni Section

Jul 08

Welcome Luisa Cochella, Ph.D., Assistant Professor

Feb 15

Andrew Holland, Ph.D. receives President’s Frontier Award

Dec 31

Josh Modell, Ph.D., awarded 2020 Johns Hopkins Discovery Award

Recent Publications

Wang Y, Venkatesh A, Xu J, Xu M, Williams J, Smallwood PM, James A, Nathans J. The WNT7A/WNT7B/GPR124/RECK signaling module plays an essential role in mammalian limb development. Development. 2022 May 1;149(9):dev200340. doi: 10.1242/dev.200340. Epub 2022 May 12. Link

Saito K, Kratzat H, Campbell A, Buschauer R, Burroughs AM, Berninghausen O, Aravind L, Green R, Beckmann R, Buskirk AR. Ribosome collisions induce mRNA cleavage and ribosome rescue in bacteria. Nature. 2022 Mar;603(7901):503-508. doi: 10.1038/s41586-022-04416-7. Epub 2022 Mar 9. Link

Poyton MF, Feng XA, Ranjan A, Lei Q, Wang F, Zarb JS, Louder RK, Park G, Jo MH, Ye J, Liu S, Ha T, Wu C. Coordinated DNA and histone dynamics drive accurate histone H2A.Z exchange. Sci Adv. 2022 Mar 11;8(10):eabj5509. doi: 10.1126/sciadv.abj5509. Epub 2022 Mar 9. Link

Saguez C, Viterbo D, Descorps-Declère S, Cormack BP, Dujon B, Richard GF. Functional variability in adhesion and flocculation of yeast megasatellite genes. Genetics. 2022 May 5;221(1):iyac042. doi: 10.1093/genetics/iyac042. Link

Ivanov IP, Saba JA, Fan CM, Wang J, Firth AE, Cao C, Green R, Dever TE. Evolutionarily conserved inhibitory uORFs sensitize Hox mRNA translation to start codon selection stringency. Proc Natl Acad Sci U S A. 2022 Mar 1;119(9):e2117226119. doi: 10.1073/pnas.2117226119. Link

Roger S Zou, Momcilo Gavrilov, Yang Liu , Dominique Rasoloson, Madison Conte, Justin Hardick, Leo Shen , Siqi Chen, Andrew Pekosz, Geraldine Seydoux, Yukari C Manabe, Taekjip Ha. Improving the specificity of nucleic acid detection with endonuclease-actuated degradation. Commun Biol. 2022 Mar 31;5(1):290.doi: 10.1038/s42003-022-03242-x. [Link]

Pascal Maguin, Andrew Varble, Joshua W Modell, Luciano A Marraffini. Cleavage of viral DNA by restriction endonucleases stimulates the type II CRISPR-Cas immune response. Mol Cell. 2022 Mar 3;82(5):907-919.e7.doi: 10.1016/j.molcel.2022.01.012. Epub 2022 Feb 7.[Link]