A natural single-guide RNA repurposes Cas9 to autoregulate CRISPR-Cas expression

Work by RE Workman and T Pammi from the Modell lab:

CRISPR-Cas systems provide their prokaryotic hosts with acquired immunity against viruses...

Multiplexed monitoring to track single cell signaling dynamics

We highlight the research of the Regot Lab:


A fundamental property of living cells is their extraordinary ability to sense and...

Scalable and versatile genome editing using linear DNAs with microhomology to Cas9 Sites in Caenorhabditis elegans

Work by Alex Paix from the Seydoux Lab:

"Homology-directed repair (HDR) of double-strand DNA breaks is a promising method for genome...

Recent Publications

Zhao S, Cordes J, Caban KM, Götz MJ, Mackens-Kiani T, Veltri AJ, Sinha NK, Weickert P, Kaya S, Hewitt G, Nedialkova DD, Fröhlich T, Beckmann R, Buskirk AR, Green R, Stingele J. RNF14-dependent atypical ubiquitylation promotes translation-coupled resolution of RNA-protein crosslinks. Mol Cell. 2023 Dec 7;83(23):4290-4303.e9. doi: 10.1016/j.molcel.2023.10.012. Epub 2023 Nov 10. PMID: 37951216. Link

Coller, J., Ignatova, Z. tRNA therapeutics for genetic diseases. Nat Rev Drug Discov (2023).

Black JJ, Green R. Saving ribosomal proteins for later. Nat Cell Biol. 2023 Nov;25(11):1568-1569. doi: 10.1038/s41556-023-01251-4. PMID: 37845326. Link

Saba JA, Huang Z, Schole KL, Ye X, Bhatt SD, Li Y, Timp W, Cheng J, Green R. LARP1 senses free ribosomes to coordinate supply and demand of ribosomal proteins. bioRxiv [Preprint]. 2023 Nov 2:2023.11.01.565189. doi: 10.1101/2023.11.01.565189. PMID: 37961604; PMCID: PMC10635049. Link

Rattner A, Heng JS, Winer BL, Goff LA, Nathans J. Normal and Sjogren’s syndrome models of the murine lacrimal gland studied at single-cell resolution. Proc Natl Acad Sci U S A. 2023 Oct 17;120(42):e2311983120. doi: 10.1073/pnas.2311983120. Epub 2023 Oct 9. PMID: 37812717; PMCID: PMC10589653. Link

Nathans J. Seeing is believing: The development of optical coherence tomography. Proc Natl Acad Sci U S A. 2023 Sep 26;120(39):e2311129120. doi: 10.1073/pnas.2311129120. Epub 2023 Sep 21. PMID: 37732756; PMCID: PMC10523475. Link

Rattner A, Wang Y, Nathans J. Signaling Pathways in Neurovascular Development. Annu Rev Neurosci. 2022 Jul 8;45:87-108. doi: 10.1146/annurev-neuro-111020-102127. PMID: 35803586. Link

Upcoming Events

April 2024

Thu, Apr 18

11:00 am – 12:30 pm
MBG Seminar: Benjamin Kleaveland. Host: Marco Catipovic

Fri, Apr 19

12:00 pm – 1:00 pm
MBG Journal Club: Chris Kim
Room 517 PCTB

Thu, Apr 25

11:00 am – 12:00 pm
MBG Colloquium: The Seydoux Lab

Fri, Apr 26

12:00 pm – 1:00 pm
MBG Journal Club: Lo-Yu Chang
Room 517 PCTB

Tue, Apr 30

11:00 am – 12:00 pm
MBG Seminar: Julian Stingele, “Nucleic acid-protein crosslinks and their resolution”