Recent Publications

Pinkard O, McFarland S, Sweet T, Coller J. Quantitative tRNA-sequencing uncovers metazoan tissue-specific tRNA regulation. Nature Communications. 2020;11(1):4104. Published 2020 Aug 14. doi:10.1038/s41467-020-17879-x [link]

Schaffer, AE, Pinkard, O., and Coller J (2019). tRNA Metabolism and Neurodevelopmental Disorders. Annual Reviews Genomics Human Genetics. PMID 31082281. [ link ] [ pdf ]

Lee, CY, Putnam, A, Lu T, He S, Ouyang JPT and Seydoux, G. Recruitment of mRNAs to P granules by condensation with intrinsically disordered proteins. Elife. 2020 Jan 24;9:e52896. doi: 10.7554/eLife.52896. [link]

Sabbagh M.F., Nathans J. (2020) A genome-wide view of the de-differentiation of central nervous system endothelial cells in culture. eLife 9:e51276 doi: 10.7554/eLife.51276. [ link ] [ pdf ]

Park, E, Scott, PM, Clutario, KM, Cassidy, KB, Zhan, K, Gerber and Holland, AJ. (2019) WBP11 is required for splicing the TUBGCP6 pre-mRNA to promote centriole duplication. Journal of Cell Biology 219 (1): e201904203. [ link ] [ pdf ]

Mercey, O*, Levine, M.S*, LoMastro, G, Rostaing, P, Brotslaw, E, Gomez, V, Kumar, A, Spassky, N, Mitchell, BJ, Meunier, A* and Holland, AJ.* (2019) Massive centriole production can occur in the absence of deuterosomes in multiciliated cells. Nature Cell Biology 21: 1544-52. (2019). *equal contribution [ link ] [ pdf ]

Alexandre Paix, Dominique Rasoloson, Andrew Folkmann, and Geraldine Seydoux (2019). Rapid Tagging of Human Proteins with Fluorescent Reporters by Genome Engineering using Double-Stranded DNA Donors. Current Protocols in Molecular Biology e102, Volume 129. [ link ]

Upcoming Events

Oct
22
Thu
MBG Seminar, Dr. Warren Grayson
Oct 22 @ 11:00 am – 12:00 pm
Oct
23
Fri
MBG Journal Club: Presenter, Tim Aikin – Regot Lab
Oct 23 @ 3:00 pm – 4:00 pm

Join Journal Club Zoom link:


https://jhjhm.zoom.us/j/99808192675?pwd=cmsyV3Z1L2FLcklNVk5RVlhhTm4xZz09

       Meeting ID: 998 0819 2675

       Passcode: 702009

Nov
13
Fri
MBG Journal Club: Presenter, Sam Sholes
Nov 13 @ 3:00 pm – 4:00 pm

Join Journal Club Zoom link:


https://jhjhm.zoom.us/j/99808192675?pwd=cmsyV3Z1L2FLcklNVk5RVlhhTm4xZz09

       Meeting ID: 998 0819 2675

       Passcode: 702009

Nov
19
Thu
MBG Seminar: Dr. Ashani Weeraratna, JHU – via Zoom (see Zoom link below)
Nov 19 @ 11:00 am – 12:00 pm

Host:  Dr. Andrew Holland

Join Zoom link:
https://jhjhm.zoom.us/j/99573486256?pwd=dElQNWtiMXFWa01hN2s3MjlYZFI4Zz09

Meeting ID: 995 7348 6256

Passcode: 964020

Nov
20
Fri
MBG Journal Club: Presenter, Phillip Scott
Nov 20 @ 3:00 pm – 4:00 pm

Join Journal Club Zoom link:


https://jhjhm.zoom.us/j/99808192675?pwd=cmsyV3Z1L2FLcklNVk5RVlhhTm4xZz09

       Meeting ID: 998 0819 2675

       Passcode: 702009

Dec
3
Thu
MBG Seminar: Dr. Angelika Amon
Dec 3 @ 11:00 am – 12:00 pm
MBG Seminar: Dr. Angelika Amon – via Zoom (see Zoom link below)
Dec 3 @ 11:00 am – 12:00 pm

Host:  Dr. Andrew Putnam

Join Zoom Link:
https://jhjhm.zoom.us/j/99573486256?pwd=dElQNWtiMXFWa01hN2s3MjlYZFI4Zz09

Meeting ID: 995 7348 6256

Passcode: 964020

Jan
28
Thu
MBG Seminar: Dr. Michael Elowitz – via Zoom (see Zoom link below)
Jan 28 @ 11:00 am – 12:00 pm

Host:  Dr. Sergi Regot

Join Zoom Link:
https://jhjhm.zoom.us/j/99573486256?pwd=dElQNWtiMXFWa01hN2s3MjlYZFI4Zz09

Meeting ID: 995 7348 6256

Passcode: 964020

A natural single-guide RNA repurposes Cas9 to autoregulate CRISPR-Cas expression

Work by RE Workman and T Pammi from the Modell lab:

CRISPR-Cas systems provide their prokaryotic hosts with acquired immunity against viruses...

Multiplexed monitoring to track single cell signaling dynamics

We highlight the research of the Regot Lab:

 

A fundamental property of living cells is their extraordinary ability to sense and...

Scalable and versatile genome editing using linear DNAs with microhomology to Cas9 Sites in Caenorhabditis elegans

Work by Alex Paix from the Seydoux Lab:

"Homology-directed repair (HDR) of double-strand DNA breaks is a promising method for genome...