Recent Publications

Wang Y, Venkatesh A, Xu J, Xu M, Williams J, Smallwood PM, James A, Nathans J. The WNT7A/WNT7B/GPR124/RECK signaling module plays an essential role in mammalian limb development. Development. 2022 May 1;149(9):dev200340. doi: 10.1242/dev.200340. Epub 2022 May 12. Link

Saito K, Kratzat H, Campbell A, Buschauer R, Burroughs AM, Berninghausen O, Aravind L, Green R, Beckmann R, Buskirk AR. Ribosome collisions induce mRNA cleavage and ribosome rescue in bacteria. Nature. 2022 Mar;603(7901):503-508. doi: 10.1038/s41586-022-04416-7. Epub 2022 Mar 9. Link

Poyton MF, Feng XA, Ranjan A, Lei Q, Wang F, Zarb JS, Louder RK, Park G, Jo MH, Ye J, Liu S, Ha T, Wu C. Coordinated DNA and histone dynamics drive accurate histone H2A.Z exchange. Sci Adv. 2022 Mar 11;8(10):eabj5509. doi: 10.1126/sciadv.abj5509. Epub 2022 Mar 9. Link

Saguez C, Viterbo D, Descorps-Declère S, Cormack BP, Dujon B, Richard GF. Functional variability in adhesion and flocculation of yeast megasatellite genes. Genetics. 2022 May 5;221(1):iyac042. doi: 10.1093/genetics/iyac042. Link

Ivanov IP, Saba JA, Fan CM, Wang J, Firth AE, Cao C, Green R, Dever TE. Evolutionarily conserved inhibitory uORFs sensitize Hox mRNA translation to start codon selection stringency. Proc Natl Acad Sci U S A. 2022 Mar 1;119(9):e2117226119. doi: 10.1073/pnas.2117226119. Link

Roger S Zou, Momcilo Gavrilov, Yang Liu , Dominique Rasoloson, Madison Conte, Justin Hardick, Leo Shen , Siqi Chen, Andrew Pekosz, Geraldine Seydoux, Yukari C Manabe, Taekjip Ha. Improving the specificity of nucleic acid detection with endonuclease-actuated degradation. Commun Biol. 2022 Mar 31;5(1):290.doi: 10.1038/s42003-022-03242-x. [Link]

Pascal Maguin, Andrew Varble, Joshua W Modell, Luciano A Marraffini. Cleavage of viral DNA by restriction endonucleases stimulates the type II CRISPR-Cas immune response. Mol Cell. 2022 Mar 3;82(5):907-919.e7.doi: 10.1016/j.molcel.2022.01.012. Epub 2022 Feb 7.[Link]

Upcoming Events

May
26
Thu
DiMaio Award Ceremony
May 26 @ 11:00 am – 12:00 pm
MBG Seminars & Colloquia
May 26 @ 11:00 am – 12:00 pm
May
27
Fri
MBG Journal Club: Marie Stoltzfus, Presenter @ Mountcastle Auditorium
May 27 @ 12:00 pm – 1:00 pm

JC Advisor: Luisa Cochella

MBG Journal Club: Vienna Huso, Presenter @ Mountcastle Auditorium
May 27 @ 12:00 pm – 1:00 pm

JC Advisor:Jeremy Nathans

Jun
2
Thu
MBG Colloquium: The Coller Lab
Jun 2 @ 11:00 am – 12:00 pm
Jun
3
Fri
MBG Journal Club: Marie Stoltzfus, Presenter @ Mountcastle Auditorium
Jun 3 @ 12:00 pm – 1:00 pm

JC Advisor: Luisa Cochella

MBG Journal Club: Will Simmons, Presenter @ Mountcastle Auditorium
Jun 3 @ 12:00 pm – 1:00 pm

JC Advisor: Jeff Coller

Jun
10
Fri
MBG Journal Club: Dev Bodas, Presenter @ Mountcastle Auditorium
Jun 10 @ 12:00 pm – 1:00 pm

JC Advisor: Brendan Cormack

Research

A natural single-guide RNA repurposes Cas9 to autoregulate CRISPR-Cas expression

Work by RE Workman and T Pammi from the Modell lab:

CRISPR-Cas systems provide their prokaryotic hosts with acquired immunity against viruses...

Multiplexed monitoring to track single cell signaling dynamics

We highlight the research of the Regot Lab:

 

A fundamental property of living cells is their extraordinary ability to sense and...

Scalable and versatile genome editing using linear DNAs with microhomology to Cas9 Sites in Caenorhabditis elegans

Work by Alex Paix from the Seydoux Lab:

"Homology-directed repair (HDR) of double-strand DNA breaks is a promising method for genome...