Recent Publications

Pokrass MJ, Ryan KA, Xin T, Pielstick B, Timp W, Greco V, Regot S. Cell Cycle Dependent ERK Signaling Dynamics Directs Fate Specification in the Mammalian Preimplantation Embryo. (2020) Developmental Cell. DOI:https://doi.org/10.1016/j.devcel.2020.09.013

Aikin T, Peterson A, Pokrass MJ, Clark HR, Regot S. MAPK Activity Dynamics Regulates Non-Cell Autonomous Effects of Oncogene Expression. (2020) Elife. Sep 17;9:e60541. https://elifesciences.org/articles/60541

Pinkard O, McFarland S, Sweet T, Coller J. Quantitative tRNA-sequencing uncovers metazoan tissue-specific tRNA regulation. Nature Communications. 2020;11(1):4104. Published 2020 Aug 14. doi:10.1038/s41467-020-17879-x [link]

Schaffer, AE, Pinkard, O., and Coller J (2019). tRNA Metabolism and Neurodevelopmental Disorders. Annual Reviews Genomics Human Genetics. PMID 31082281. [ link ] [ pdf ]

Lee, CY, Putnam, A, Lu T, He S, Ouyang JPT and Seydoux, G. Recruitment of mRNAs to P granules by condensation with intrinsically disordered proteins. Elife. 2020 Jan 24;9:e52896. doi: 10.7554/eLife.52896. [link]

Sabbagh M.F., Nathans J. (2020) A genome-wide view of the de-differentiation of central nervous system endothelial cells in culture. eLife 9:e51276 doi: 10.7554/eLife.51276. [ link ] [ pdf ]

Park, E, Scott, PM, Clutario, KM, Cassidy, KB, Zhan, K, Gerber and Holland, AJ. (2019) WBP11 is required for splicing the TUBGCP6 pre-mRNA to promote centriole duplication. Journal of Cell Biology 219 (1): e201904203. [ link ] [ pdf ]

Upcoming Events

Jan
28
Thu
MBG Seminar: Michael Elowitz, Ph.D., California Institute of Technology
Jan 28 @ 3:00 pm – 4:00 pm

“Circuit designs for natural and synthetic multicellular systems”

Speaker:  Michael Elowitz, Ph.D.
Professor of Biology, Bioengineering and Applied Physics; Bren Scholar
Investigator, Howard Hughes Medical Institute
California Institute of Technology

Host:  Sergi Regot, Ph.D.

Jan
29
Fri
MBG Journal Club via Zoom – link to follow
Jan 29 @ 3:00 pm – 4:00 pm
MBG Journal Club: Presenter, Colin Gliech
Jan 29 @ 3:00 pm – 4:00 pm

Join Journal Club Zoom link:


https://jhjhm.zoom.us/j/99808192675?pwd=cmsyV3Z1L2FLcklNVk5RVlhhTm4xZz09

       Meeting ID: 998 0819 2675

       Passcode: 702009

Feb
5
Fri
MBG Journal Club via Zoom – link to follow
Feb 5 @ 3:00 pm – 4:00 pm
MBG Journal Club: Presenter, Amy Peterson
Feb 5 @ 3:00 pm – 4:00 pm

Join Journal Club Zoom link:


https://jhjhm.zoom.us/j/99808192675?pwd=cmsyV3Z1L2FLcklNVk5RVlhhTm4xZz09

       Meeting ID: 998 0819 2675

       Passcode: 702009

Feb
11
Thu
MBG Seminar: Fadel Tissir, Ph.D., Professor, University of Louvain, Brussels, Belgium
Feb 11 @ 11:00 am – 12:00 pm

The fragile balance betweenproliferation and neoplasia: Implication of Diaph3 in neurogenesis andglioblastoma”

Host:  Dr. Jeremy Nathans
 

Feb
12
Fri
MBG Journal Club via Zoom – link to follow
Feb 12 @ 3:00 pm – 4:00 pm
MBG Journal Club: Presenter, Gina LoMastro
Feb 12 @ 3:00 pm – 4:00 pm

Join Journal Club Zoom link:


https://jhjhm.zoom.us/j/99808192675?pwd=cmsyV3Z1L2FLcklNVk5RVlhhTm4xZz09

       Meeting ID: 998 0819 2675

       Passcode: 702009

Research

A natural single-guide RNA repurposes Cas9 to autoregulate CRISPR-Cas expression

Work by RE Workman and T Pammi from the Modell lab:

CRISPR-Cas systems provide their prokaryotic hosts with acquired immunity against viruses...

Multiplexed monitoring to track single cell signaling dynamics

We highlight the research of the Regot Lab:

 

A fundamental property of living cells is their extraordinary ability to sense and...

Scalable and versatile genome editing using linear DNAs with microhomology to Cas9 Sites in Caenorhabditis elegans

Work by Alex Paix from the Seydoux Lab:

"Homology-directed repair (HDR) of double-strand DNA breaks is a promising method for genome...