Recent Publications

Workman RE, Pammi T, Nguyen BTK, Graeff LW, Smith E, Sebald SM, Stoltzfus MJ, Euler CW, Modell JW. (2021) A natural single guide RNA repurposes Cas9 to autoregulate CRISPR-Cas expression. Cell. 2021 Jan 6:S0092-8674(20)31687-1. doi: 10.1016/j.cell.2020.12.017. Epub ahead of print. PMID: 33421369. [link] [pdf]
Pokrass MJ, Ryan KA, Xin T, Pielstick B, Timp W, Greco V, Regot S. Cell Cycle Dependent ERK Signaling Dynamics Directs Fate Specification in the Mammalian Preimplantation Embryo. (2020) Developmental Cell. [link] [pdf]

Aikin T, Peterson A, Pokrass MJ, Clark HR, Regot S. MAPK Activity Dynamics Regulates Non-Cell Autonomous Effects of Oncogene Expression. (2020) Elife. Sep 17;9:e60541. [link] [pdf]

Rattner A, Terrillion CE, Jou C, Kleven T, Hu SF, Williams J, Hou Z, Aggarwal M, Mori S, Shin G, Goff LA, Witter MP, Pletnikov M, Fenton AA, Nathans J. (2020) Developmental, cellular, and behavioral phenotypes in a mouse model of congenital hypoplasia of the dentate gyrus. Elife. 9:e62766. doi: 10.7554/eLife.62766. PMID: 33084572 [link]

Pinkard O, McFarland S, Sweet T, Coller J. Quantitative tRNA-sequencing uncovers metazoan tissue-specific tRNA regulation. Nature Communications. 2020;11(1):4104. Published 2020 Aug 14. doi:10.1038/s41467-020-17879-x [link]

Schaffer, AE, Pinkard, O., and Coller J (2019). tRNA Metabolism and Neurodevelopmental Disorders. Annual Reviews Genomics Human Genetics. PMID 31082281. [ link ] [ pdf ]

Chang TH, Hsieh FL, Smallwood PM, Gabelli SB, Nathans J. (2020) Structure of the RECK CC domain, an evolutionary anomaly. Proceedings of the National Academy of Sciences of the United States of America.117(26):15104-15111. doi: 10.1073/pnas.2006332117. Epub 2020 Jun 15. PMID: 32541044 [link]

Upcoming Events

Racial Justice in STEM Seminar: Dr. Kimberly Griffin, University of Maryland
Apr 16 @ 11:00 am – 12:00 pm

Friday, April 16, 2021
Virtual seminar at 11 am

Speaker:  Dr. Kimberly A. Griffin, Ph.D.
University of Maryland

“Supporting early career scholars of color in STEM: Moving beyond navigating barriers to equity based interventions”

Hosted by Rachel Green & Miguel Pacheco

MBG Journal Club: Presenter, Nicholas Keith
Apr 16 @ 3:00 pm – 4:00 pm
MBG Colloquium – Wu Lab
Apr 22 @ 11:00 am – 12:00 pm
MBG Journal Club: Presenter, Will Simmons
Apr 23 @ 3:00 pm – 4:00 pm
MBG Seminar: Karine Gibbs, Ph.D., University of California, Berkeley
Apr 29 @ 11:00 am – 12:00 pm

Speaker:  Karine A. Gibbs, Ph.D.
Associate Professor
Department of Plant and Microbial Biology
University of California, Berkeley

Visiting Scholar
Department of Molecular and Cellular Biology
Harvard University

Title of seminar TBA.

Host:  Joshua Modell, Ph.D.

MBG Journal Club: Presenter, Jeeun Song
Apr 30 @ 3:00 pm – 4:00 pm
MBG Special Colloquium: DiMaio Award Presentation
May 6 @ 11:00 am – 12:30 pm
MBG Journal Club: Presenter, JP Ouyang
May 7 @ 3:00 pm – 4:00 pm


A natural single-guide RNA repurposes Cas9 to autoregulate CRISPR-Cas expression

Work by RE Workman and T Pammi from the Modell lab:

CRISPR-Cas systems provide their prokaryotic hosts with acquired immunity against viruses...

Multiplexed monitoring to track single cell signaling dynamics

We highlight the research of the Regot Lab:


A fundamental property of living cells is their extraordinary ability to sense and...

Scalable and versatile genome editing using linear DNAs with microhomology to Cas9 Sites in Caenorhabditis elegans

Work by Alex Paix from the Seydoux Lab:

"Homology-directed repair (HDR) of double-strand DNA breaks is a promising method for genome...