Recent Publications

Pinkard O, McFarland S, Sweet T, Coller J. Quantitative tRNA-sequencing uncovers metazoan tissue-specific tRNA regulation. Nature Communications. 2020;11(1):4104. Published 2020 Aug 14. doi:10.1038/s41467-020-17879-x [link]

Schaffer, AE, Pinkard, O., and Coller J (2019). tRNA Metabolism and Neurodevelopmental Disorders. Annual Reviews Genomics Human Genetics. PMID 31082281. [ link ] [ pdf ]

Sabbagh M.F., Nathans J. (2020) A genome-wide view of the de-differentiation of central nervous system endothelial cells in culture. eLife 9:e51276 doi: 10.7554/eLife.51276. [ link ] [ pdf ]

Park, E, Scott, PM, Clutario, KM, Cassidy, KB, Zhan, K, Gerber and Holland, AJ. (2019) WBP11 is required for splicing the TUBGCP6 pre-mRNA to promote centriole duplication. Journal of Cell Biology 219 (1): e201904203. [ link ] [ pdf ]

Mercey, O*, Levine, M.S*, LoMastro, G, Rostaing, P, Brotslaw, E, Gomez, V, Kumar, A, Spassky, N, Mitchell, BJ, Meunier, A* and Holland, AJ.* (2019) Massive centriole production can occur in the absence of deuterosomes in multiciliated cells. Nature Cell Biology 21: 1544-52. (2019). *equal contribution [ link ] [ pdf ]

Alexandre Paix, Dominique Rasoloson, Andrew Folkmann, and Geraldine Seydoux (2019). Rapid Tagging of Human Proteins with Fluorescent Reporters by Genome Engineering using Double-Stranded DNA Donors. Current Protocols in Molecular Biology e102, Volume 129. [ link ]

Heng J.S., Hackett S.F., Stein-O’Brien G.L., Winer B.L., Williams J., Goff L.A., Nathans J. (2019) Comprehensive analysis of a mouse model of spontaneous uveoretinitis using single-cell RNA sequencing. Proceedings of the National Academy of Sciences of the United States of America 116 (52) 26734-26744. [ link ] [ pdf ]

Upcoming Events

Sep
22
Tue
BCMB 2020 Symposium, Session #3 @
Sep 22 @ 3:00 pm – 4:00 pm

Tue – 09/22 (3PM): Breann Brown (Vanderbilt U) / Joyce Lee (Berger lab)

Join Zoom meeting:

https://JHUBlueJays.zoom.us/j/92504242077?pwd=bm5FV3UzaXF5SG8wcm54aHEyNzZNUT09
Meeting ID: 925 0424 2077
Passcode: 557259

Sep
25
Fri
MBG Journal Club via Zoom – link to follow
Sep 25 @ 3:00 pm – 4:00 pm
Sep
29
Tue
BCMB 2020 Symposium, Session #1
Sep 29 @ 3:00 pm – 4:00 pm

Tue 09/29 (3PM): Arjun Raj (U Penn) / Josh McCausland (Xiao lab)

Join Zoom meeting:

https://JHUBlueJays.zoom.us/j/92504242077?pwd=bm5FV3UzaXF5SG8wcm54aHEyNzZNUT09
Meeting ID: 925 0424 2077
Passcode: 557259

Oct
2
Fri
MBG Journal Club via Zoom – link to follow
Oct 2 @ 3:00 pm – 4:00 pm
Oct
6
Tue
BCMB 2020 Symposium, Session #4
Oct 6 @ 3:00 pm – 4:00 pm

Tue – 10/06 (3PM): David Page (MIT, HHMI) / Linhao Ruan (Li lab)

Join Zoom meeting:

https://JHUBlueJays.zoom.us/j/92504242077?pwd=bm5FV3UzaXF5SG8wcm54aHEyNzZNUT09
Meeting ID: 925 0424 2077
Passcode: 557259

Oct
9
Fri
MBG Journal Club via Zoom – link to follow
Oct 9 @ 3:00 pm – 4:00 pm
Oct
13
Tue
BCMB 2020 Symposium, Session #1
Oct 13 @ 11:00 am – 12:00 pm

Tue – 10/13 (11AM): Sabine Petry (Princeton U) / Helen Clark (Regot lab)

Join Zoom meeting:

https://JHUBlueJays.zoom.us/j/92504242077?pwd=bm5FV3UzaXF5SG8wcm54aHEyNzZNUT09
Meeting ID: 925 0424 2077
Passcode: 557259

Oct
16
Fri
MBG Journal Club via Zoom – link to follow
Oct 16 @ 3:00 pm – 4:00 pm

A natural single-guide RNA repurposes Cas9 to autoregulate CRISPR-Cas expression

Work by RE Workman and T Pammi from the Modell lab:

CRISPR-Cas systems provide their prokaryotic hosts with acquired immunity against viruses...

Multiplexed monitoring to track single cell signaling dynamics

We highlight the research of the Regot Lab:

 

A fundamental property of living cells is their extraordinary ability to sense and...

Scalable and versatile genome editing using linear DNAs with microhomology to Cas9 Sites in Caenorhabditis elegans

Work by Alex Paix from the Seydoux Lab:

"Homology-directed repair (HDR) of double-strand DNA breaks is a promising method for genome...