Nov 17
Research
A natural single-guide RNA repurposes Cas9 to autoregulate CRISPR-Cas expression
Work by RE Workman and T Pammi from the Modell lab:
CRISPR-Cas systems provide their prokaryotic hosts with acquired immunity against viruses...
Multiplexed monitoring to track single cell signaling dynamics
We highlight the research of the Regot Lab:
A fundamental property of living cells is their extraordinary ability to sense and...
Scalable and versatile genome editing using linear DNAs with microhomology to Cas9 Sites in Caenorhabditis elegans
Work by Alex Paix from the Seydoux Lab:
"Homology-directed repair (HDR) of double-strand DNA breaks is a promising method for genome...
News
Nov 14
Aug 14
Aug 14
Mar 12
Dec 16
Jul 15
Recent Publications
Vera for her publication, “Antigen affinity modulates ERK pulsing frequency during T cell activation” in the journal Science Signaling! Click link get more information.
January 13, 2026
Keith NC, Snyder RA, Euler CW, Modell JW. Bacteria exploit viral dormancy to establish CRISPR-Cas immunity. Cell Host Microbe. 2025 Mar 12;33(3):330-340.e6. doi: 10.1016/j.chom.2025.02.001.
Ghosh S, Bandyopadhyay S, Smith DM, Adak S, Semenkovich CF, Nagy L, Wolfgang MJ, O’Connor TJ. Legionella usurps host cell lipids for vacuole expansion and bacterial growth. PLoS Pathogens. 2024. 20:e1011996. doi: 10.1371/journal.ppat.1011996. PMID: 38386622
Hossain, MJ, Romanov KA, Jian J, Swaby LC, Bandyopadhyay S, Guan I, Thomas SM, Olive AJ, O’Connor TJ. Bacterial pathogens hijack host cell peroxisomes for replication vacuole membrane expansion and integrity. Science Advances. 2025. 11:eadr8005. doi: 10.1126/sciadv.adr8005. PMID: 40305606
Marie J. Stoltzfus, Rachael E. Workman, Nicholas C. Keith, Joshua W. Modell
bioRxiv 2024.01.11.575229; doi: https://doi.org/10.1101/2024.01.11.575229 [preprint]
Mandlbauer A, Sun Q, Popitsch N, Schwickert T, Spanova M, Wang J, Ameres SL, Busslinger M, Cochella L. Mime-seq 2.0: a method to sequence microRNAs from specific mouse cell types. EMBO J. 2024 Apr 30. doi: 10.1038/s44318-024-00102-8. PMID: 38689024
Stoltzfus MJ, Workman RE, Keith NC, Modell JW. A dynamic subpopulation of CRISPR-Cas overexpressers allows Streptococcus pyogenes to rapidly respond to phage. Nat Microbiol. 2024 Sep;9(9):2410-2421. doi: 10.1038/s41564-024-01748-0. Epub 2024 Jul 12. PMID: 38997519; PMCID: PMC11983678.