Recent Publications

John Paul Tsu Ouyang, Wenyan Lucy Zhang and Geraldine Seydoux. The conserved helicase ZNFX-1 memorializes silenced RNAs in perinuclear condensates. Nature Cell Biology, 2022.
Link

Wang Y, Venkatesh A, Xu J, Xu M, Williams J, Smallwood PM, James A, Nathans J. The WNT7A/WNT7B/GPR124/RECK signaling module plays an essential role in mammalian limb development. Development. 2022 May 1;149(9):dev200340. doi: 10.1242/dev.200340. Epub 2022 May 12. Link

Saito K, Kratzat H, Campbell A, Buschauer R, Burroughs AM, Berninghausen O, Aravind L, Green R, Beckmann R, Buskirk AR. Ribosome collisions induce mRNA cleavage and ribosome rescue in bacteria. Nature. 2022 Mar;603(7901):503-508. doi: 10.1038/s41586-022-04416-7. Epub 2022 Mar 9. Link

Poyton MF, Feng XA, Ranjan A, Lei Q, Wang F, Zarb JS, Louder RK, Park G, Jo MH, Ye J, Liu S, Ha T, Wu C. Coordinated DNA and histone dynamics drive accurate histone H2A.Z exchange. Sci Adv. 2022 Mar 11;8(10):eabj5509. doi: 10.1126/sciadv.abj5509. Epub 2022 Mar 9. Link

Saguez C, Viterbo D, Descorps-Declère S, Cormack BP, Dujon B, Richard GF. Functional variability in adhesion and flocculation of yeast megasatellite genes. Genetics. 2022 May 5;221(1):iyac042. doi: 10.1093/genetics/iyac042. Link

Ivanov IP, Saba JA, Fan CM, Wang J, Firth AE, Cao C, Green R, Dever TE. Evolutionarily conserved inhibitory uORFs sensitize Hox mRNA translation to start codon selection stringency. Proc Natl Acad Sci U S A. 2022 Mar 1;119(9):e2117226119. doi: 10.1073/pnas.2117226119. Link

Roger S Zou, Momcilo Gavrilov, Yang Liu , Dominique Rasoloson, Madison Conte, Justin Hardick, Leo Shen , Siqi Chen, Andrew Pekosz, Geraldine Seydoux, Yukari C Manabe, Taekjip Ha. Improving the specificity of nucleic acid detection with endonuclease-actuated degradation. Commun Biol. 2022 Mar 31;5(1):290.doi: 10.1038/s42003-022-03242-x. [Link]

Upcoming Events

Feb
9
Thu
MBG Faculty Seminar – Josh Modell @ Mountcastle Auditorium
Feb 9 @ 4:00 pm – 5:00 pm
Modell Lab Poster Session and Happy Hour @ Greenhouse Cafe
Feb 9 @ 5:00 pm – 6:00 pm
Feb
16
Thu
MBG Seminar: Dr. Tobias Meyer, Cornell University @ Mountcastle Auditorium in the Preclinical Teaching Building
Feb 16 @ 11:00 am – 12:00 pm

Host: Dr. Sergi Regot

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Feb
17
Fri
MBG Journal Club: Will Simmons @ 517 PCTB
Feb 17 @ 12:00 pm – 1:00 pm
Feb
24
Fri
MBG Journal Club: Connor McKenney @ 517 PCTB
Feb 24 @ 12:00 pm – 1:00 pm
Mar
2
Thu
MBG Collloquium: The Cochella Lab @ 517 PCTB
Mar 2 @ 11:00 am – 12:00 pm

For questions regarding this MBG Seminar, please contact Cindy Rogers at crogers4@jhmi.edu.

Mar
3
Fri
MBG Journal Club: Brennan Danlasky @ 517 PCTB
Mar 3 @ 12:00 pm – 1:00 pm
Mar
9
Thu
MBG Seminar: Dr. Pallav Kosuri, Salk Institute for Biological Studies @ Mountcastle Auditorium in the Preclinical Teaching Building
Mar 9 @ 11:00 am – 12:00 pm

Host: Dr. Rachel Green

Research

A natural single-guide RNA repurposes Cas9 to autoregulate CRISPR-Cas expression

Work by RE Workman and T Pammi from the Modell lab:

CRISPR-Cas systems provide their prokaryotic hosts with acquired immunity against viruses...

Multiplexed monitoring to track single cell signaling dynamics

We highlight the research of the Regot Lab:

 

A fundamental property of living cells is their extraordinary ability to sense and...

Scalable and versatile genome editing using linear DNAs with microhomology to Cas9 Sites in Caenorhabditis elegans

Work by Alex Paix from the Seydoux Lab:

"Homology-directed repair (HDR) of double-strand DNA breaks is a promising method for genome...