Recent Publications

Sabbagh M.F., Nathans J. (2020) A genome-wide view of the de-differentiation of central nervous system endothelial cells in culture. eLife 9:e51276 doi: 10.7554/eLife.51276. [ link ] [ pdf ]
Park, E, Scott, PM, Clutario, KM, Cassidy, KB, Zhan, K, Gerber and Holland, AJ. (2019) WBP11 is required for splicing the TUBGCP6 pre-mRNA to promote centriole duplication. Journal of Cell Biology 219 (1): e201904203. [ link ] [ pdf ]
Mercey, O*, Levine, M.S*, LoMastro, G, Rostaing, P, Brotslaw, E, Gomez, V, Kumar, A, Spassky, N, Mitchell, BJ, Meunier, A* and Holland, AJ.* (2019) Massive centriole production can occur in the absence of deuterosomes in multiciliated cells. Nature Cell Biology 21: 1544-52. (2019). *equal contribution [ link ] [ pdf ]
Alexandre Paix, Dominique Rasoloson, Andrew Folkmann, and Geraldine Seydoux (2019). Rapid Tagging of Human Proteins with Fluorescent Reporters by Genome Engineering using Double-Stranded DNA Donors. Current Protocols in Molecular Biology e102, Volume 129. [ link ]
Heng J.S., Hackett S.F., Stein-O'Brien G.L., Winer B.L., Williams J., Goff L.A., Nathans J. (2019) Comprehensive analysis of a mouse model of spontaneous uveoretinitis using single-cell RNA sequencing. Proceedings of the National Academy of Sciences of the United States of America 116 (52) 26734-26744. [ link ] [ pdf ]
Ouyang, JPT, Folkmann, A, Bernard, L, Lee, CY, Seroussi, U, Charlesworth, AG et al. P Granules Protect RNA Interference Genes from Silencing by piRNAs. Dev. Cell. 2019</u>; :. doi: 10.1016/j.devcel.2019.07.026. [ pdf ]

Upcoming Events

Actin-propelled invasive membrane protrusions promote fusogenic protein engagement during cell-cell fusion.

Cell-cell fusion is critical for the conception, development, and physiology of multicellular organisms. Although cellular fusogenic proteins and the actin...

Multiplexed monitoring to track single cell signaling dynamics

We highlight the research of the Regot Lab:

 

A fundamental property of living cells is their extraordinary ability to sense and...

Scalable and versatile genome editing using linear DNAs with microhomology to Cas9 Sites in Caenorhabditis elegans

Work by Alex Paix from the Seydoux Lab:

"Homology-directed repair (HDR) of double-strand DNA breaks is a promising method for genome...