Recent Publications

Andrew W Folkmann, Andrea Putnam, Chiu Fan Lee, Geraldine Seydoux. Regulation of biomolecular condensates by interfacial protein clusters. Science 2021 Sep 10;373(6560):1218-1224. doi: 10.1126/science.abg7071. Epub 2021 Sep 9. [Link]

Amer A Hossain 1 , Jon McGinn 1 , Alexander J Meeske 1 , Joshua W Modell 2 , Luciano A Marraffini. Viral recombination systems limit CRISPR-Cas targeting through the generation of escape mutations. Cell Host Microbe. 2021 Sep 22;S1931-3128(21)00417-0. doi: 10.1016/j.chom.2021.09.001. Online ahead of print. [Link]

Andrew W. Folkmann, Andrea Putnam, Chiu Fan Lee and Geraldine Seydoux. Regulation of biomolecular condensates by interfacial protein clusters. Science, 10 Sep 2021, Vol 373, Issue 6560, pp. 1218-1224. Link

Jeronimo C, Angel A, Nguyen VQ, Kim JM, Poitras C, Lambert E, Collin P, Mellor J, Wu C, Robert F. FACT is recruited to the +1 nucleosome of transcribed genes and spreads in a Chd1-dependent manner. Mol Cell. 2021 Aug 5:S1097-2765(21)00579-7. doi: 10.1016/j.molcel.2021.07.010. Epub ahead of print. PMID: 34380014.

Nguyen VQ, Ranjan A, Liu S, Tang X, Ling YH, Wisniewski J, Mizuguchi G, Li KY, Jou V, Zheng Q, Lavis LD, Lionnet T, Wu C. Spatiotemporal coordination of transcription preinitiation complex assembly in live cells. Mol Cell. 2021 Aug 2:S1097-2765(21)00591-8. doi: 10.1016/j.molcel.2021.07.022. Epub ahead of print. PMID: 34375585.

Kim JM, Visanpattanasin P, Jou V, Liu S, Tang X, Zheng Q, Li KY, Snedeker J, Lavis LD, Lionnet T, Wu C. Single-molecule imaging of chromatin remodelers reveals role of ATPase in promoting fast kinetics of target search and dissociation from chromatin. Elife. 2021 Jul 27;10:e69387. doi: 10.7554/eLife.69387. PMID: 34313223; PMCID: PMC8352589.

Calderón L, Schindler K, Malin SG, Schebesta A, Sun Q, Schwickert T, Alberti C, Fischer M, Jaritz M, Tagoh H, Ebert A, Minnich M, Liston A, Cochella L, Busslinger M. Pax5 regulates B cell immunity by promoting PI3K signaling via PTEN down-regulation. Sci Immunol. 2021 Jul 23;6(61):eabg5003. doi: 10.1126/sciimmunol.abg5003. PMID: 34301800; PMCID: PMC7611449.


A natural single-guide RNA repurposes Cas9 to autoregulate CRISPR-Cas expression

Work by RE Workman and T Pammi from the Modell lab:

CRISPR-Cas systems provide their prokaryotic hosts with acquired immunity against viruses...

Multiplexed monitoring to track single cell signaling dynamics

We highlight the research of the Regot Lab:


A fundamental property of living cells is their extraordinary ability to sense and...

Scalable and versatile genome editing using linear DNAs with microhomology to Cas9 Sites in Caenorhabditis elegans

Work by Alex Paix from the Seydoux Lab:

"Homology-directed repair (HDR) of double-strand DNA breaks is a promising method for genome...