Recent Publications

Workman RE, Pammi T, Nguyen BTK, Graeff LW, Smith E, Sebald SM, Stoltzfus MJ, Euler CW, Modell JW. (2021) A natural single guide RNA repurposes Cas9 to autoregulate CRISPR-Cas expression. Cell. 2021 Jan 6:S0092-8674(20)31687-1. doi: 10.1016/j.cell.2020.12.017. Epub ahead of print. PMID: 33421369. [link] [pdf]
Pokrass MJ, Ryan KA, Xin T, Pielstick B, Timp W, Greco V, Regot S. Cell Cycle Dependent ERK Signaling Dynamics Directs Fate Specification in the Mammalian Preimplantation Embryo. (2020) Developmental Cell. [link] [pdf]

Aikin T, Peterson A, Pokrass MJ, Clark HR, Regot S. MAPK Activity Dynamics Regulates Non-Cell Autonomous Effects of Oncogene Expression. (2020) Elife. Sep 17;9:e60541. [link] [pdf]

Rattner A, Terrillion CE, Jou C, Kleven T, Hu SF, Williams J, Hou Z, Aggarwal M, Mori S, Shin G, Goff LA, Witter MP, Pletnikov M, Fenton AA, Nathans J. (2020) Developmental, cellular, and behavioral phenotypes in a mouse model of congenital hypoplasia of the dentate gyrus. Elife. 9:e62766. doi: 10.7554/eLife.62766. PMID: 33084572 [link]

Pinkard O, McFarland S, Sweet T, Coller J. Quantitative tRNA-sequencing uncovers metazoan tissue-specific tRNA regulation. Nature Communications. 2020;11(1):4104. Published 2020 Aug 14. doi:10.1038/s41467-020-17879-x [link]

Schaffer, AE, Pinkard, O., and Coller J (2019). tRNA Metabolism and Neurodevelopmental Disorders. Annual Reviews Genomics Human Genetics. PMID 31082281. [ link ] [ pdf ]

Chang TH, Hsieh FL, Smallwood PM, Gabelli SB, Nathans J. (2020) Structure of the RECK CC domain, an evolutionary anomaly. Proceedings of the National Academy of Sciences of the United States of America.117(26):15104-15111. doi: 10.1073/pnas.2006332117. Epub 2020 Jun 15. PMID: 32541044 [link]

Upcoming Events

Mar
4
Thu
MBG DIWG Seminar: Lawrence Brown, Ph.D.
Mar 4 @ 11:00 am – 12:00 pm

Speaker:  Lawrence Brown, Ph.D. (Pre-recorded)

Visiting Professor, University of Wisconsin Population Health Institute

Mapping Baltimore Apartheid” – African American History in Maryland and Beyond

 


 

Mar
5
Fri
MBG Journal Club: Presenter, Marie Stoltzfus
Mar 5 @ 3:00 pm – 4:00 pm
Mar
11
Thu
MBG Responsible Conduct of Research Special Colloquium
Mar 11 @ 11:00 am – 12:30 pm
Mar
12
Fri
MBG Journal Club: Presenter, Rachel Sparklin
Mar 12 @ 3:00 pm – 4:00 pm
Mar
18
Thu
MBG DIWG Seminar: Small Group Discussions
Mar 18 @ 11:00 am – 12:00 pm
Mar
19
Fri
MBG Journal Club: Presenter, Connor McKenney
Mar 19 @ 3:00 pm – 4:00 pm
Mar
25
Thu
MBG Colloquium – Holland Lab
Mar 25 @ 11:00 am – 12:00 pm
Mar
26
Fri
MBG Journal Club: Presenter, Esther Park
Mar 26 @ 3:00 pm – 4:00 pm

Research

A natural single-guide RNA repurposes Cas9 to autoregulate CRISPR-Cas expression

Work by RE Workman and T Pammi from the Modell lab:

CRISPR-Cas systems provide their prokaryotic hosts with acquired immunity against viruses...

Multiplexed monitoring to track single cell signaling dynamics

We highlight the research of the Regot Lab:

 

A fundamental property of living cells is their extraordinary ability to sense and...

Scalable and versatile genome editing using linear DNAs with microhomology to Cas9 Sites in Caenorhabditis elegans

Work by Alex Paix from the Seydoux Lab:

"Homology-directed repair (HDR) of double-strand DNA breaks is a promising method for genome...