Recent Publications

John Paul Tsu Ouyang, Wenyan Lucy Zhang and Geraldine Seydoux. The conserved helicase ZNFX-1 memorializes silenced RNAs in perinuclear condensates. Nature Cell Biology, 2022.
Link

Wang Y, Venkatesh A, Xu J, Xu M, Williams J, Smallwood PM, James A, Nathans J. The WNT7A/WNT7B/GPR124/RECK signaling module plays an essential role in mammalian limb development. Development. 2022 May 1;149(9):dev200340. doi: 10.1242/dev.200340. Epub 2022 May 12. Link

Saito K, Kratzat H, Campbell A, Buschauer R, Burroughs AM, Berninghausen O, Aravind L, Green R, Beckmann R, Buskirk AR. Ribosome collisions induce mRNA cleavage and ribosome rescue in bacteria. Nature. 2022 Mar;603(7901):503-508. doi: 10.1038/s41586-022-04416-7. Epub 2022 Mar 9. Link

Poyton MF, Feng XA, Ranjan A, Lei Q, Wang F, Zarb JS, Louder RK, Park G, Jo MH, Ye J, Liu S, Ha T, Wu C. Coordinated DNA and histone dynamics drive accurate histone H2A.Z exchange. Sci Adv. 2022 Mar 11;8(10):eabj5509. doi: 10.1126/sciadv.abj5509. Epub 2022 Mar 9. Link

Saguez C, Viterbo D, Descorps-Declère S, Cormack BP, Dujon B, Richard GF. Functional variability in adhesion and flocculation of yeast megasatellite genes. Genetics. 2022 May 5;221(1):iyac042. doi: 10.1093/genetics/iyac042. Link

Ivanov IP, Saba JA, Fan CM, Wang J, Firth AE, Cao C, Green R, Dever TE. Evolutionarily conserved inhibitory uORFs sensitize Hox mRNA translation to start codon selection stringency. Proc Natl Acad Sci U S A. 2022 Mar 1;119(9):e2117226119. doi: 10.1073/pnas.2117226119. Link

Roger S Zou, Momcilo Gavrilov, Yang Liu , Dominique Rasoloson, Madison Conte, Justin Hardick, Leo Shen , Siqi Chen, Andrew Pekosz, Geraldine Seydoux, Yukari C Manabe, Taekjip Ha. Improving the specificity of nucleic acid detection with endonuclease-actuated degradation. Commun Biol. 2022 Mar 31;5(1):290.doi: 10.1038/s42003-022-03242-x. [Link]

Upcoming Events

Oct
6
Thu
MBG Colloquium: The Nathans Lab @ Mountcastle Auditorium
Oct 6 @ 11:00 am – 12:00 pm

For questions regarding this MBG Seminar, please contact Cindy Rogers at crogers4@jhmi.edu.

Oct
20
Thu
MBG Colloquium: The Coller Lab
Oct 20 @ 11:00 am – 12:00 pm

For questions regarding this MBG Seminar, please contact Cindy Rogers at crogers4@jhmi.edu.

Oct
27
Thu
MBG Colloquium: The Holland Lab
Oct 27 @ 11:00 am – 12:00 pm

For questions regarding this MBG Seminar, please contact Cindy Rogers at crogers4@jhmi.edu.

Nov
3
Thu
MBG Seminar: Dr. Stephen Floor, UCSF @ Mountcastle Auditorium
Nov 3 @ 11:00 am – 12:00 pm

Host: Dr. Rachel Green

For questions regarding this MBG Seminar, please contact Cindy Rogers at crogers4@jhmi.edu.

Nov
17
Thu
MBG Seminar: Dr. Moonjung, Division of Hematology, JHU @ Mountcastle Auditorium
Nov 17 @ 11:00 am – 12:00 pm

Host: Dr. Mary Armanios

For questions regarding this MBG Seminar, please contact Cindy Rogers at crogers4@jhmi.edu.

Dec
1
Thu
MBG Seminar: Dr. Sua Myong, Dept of Biophysics, JHU @ Mountcastle Auditorium
Dec 1 @ 11:00 am – 12:00 pm

Host: Dr. Jeremy Nathans

For questions regarding this MBG Seminar, please contact Cindy Rogers at crogers4@jhmi.edu.

Dec
8
Thu
MBG Seminar: Dr. Monica Gotta, University of Geneva @ Mountcastle Auditorium
Dec 8 @ 11:00 am – 12:00 pm

Host: Dr. Geraldine Seydoux

For questions regarding this MBG Seminar, please contact Cindy Rogers at crogers4@jhmi.edu.

Jan
12
Thu
MBG Colloquium: The Seydoux Lab
Jan 12 @ 11:00 am – 12:00 pm

For questions regarding this MBG Seminar, please contact Cindy Rogers at crogers4@jhmi.edu.

Research

A natural single-guide RNA repurposes Cas9 to autoregulate CRISPR-Cas expression

Work by RE Workman and T Pammi from the Modell lab:

CRISPR-Cas systems provide their prokaryotic hosts with acquired immunity against viruses...

Multiplexed monitoring to track single cell signaling dynamics

We highlight the research of the Regot Lab:

 

A fundamental property of living cells is their extraordinary ability to sense and...

Scalable and versatile genome editing using linear DNAs with microhomology to Cas9 Sites in Caenorhabditis elegans

Work by Alex Paix from the Seydoux Lab:

"Homology-directed repair (HDR) of double-strand DNA breaks is a promising method for genome...