Work by RE Workman and T Pammi from the Modell lab:
CRISPR-Cas systems provide their prokaryotic hosts with acquired immunity against viruses...
We highlight the research of the Regot Lab:
A fundamental property of living cells is their extraordinary ability to sense and...
Work by Alex Paix from the Seydoux Lab:
"Homology-directed repair (HDR) of double-strand DNA breaks is a promising method for genome...
Ghosh S, Bandyopadhyay S, Smith DM, Adak S, Semenkovich CF, Nagy L, Wolfgang MJ, O’Connor TJ. Legionella usurps host cell lipids for vacuole expansion and bacterial growth. PLoS Pathogens. 2024. 20:e1011996. doi: 10.1371/journal.ppat.1011996. PMID: 38386622
Hossain, MJ, Romanov KA, Jian J, Swaby LC, Bandyopadhyay S, Guan I, Thomas SM, Olive AJ, O’Connor TJ. Bacterial pathogens hijack host cell peroxisomes for replication vacuole membrane expansion and integrity. Science Advances. 2025. 11:eadr8005. doi: 10.1126/sciadv.adr8005. PMID: 40305606
Marie J. Stoltzfus, Rachael E. Workman, Nicholas C. Keith, Joshua W. Modell
bioRxiv 2024.01.11.575229; doi: https://doi.org/10.1101/2024.01.11.575229 [preprint]
Mandlbauer A, Sun Q, Popitsch N, Schwickert T, Spanova M, Wang J, Ameres SL, Busslinger M, Cochella L. Mime-seq 2.0: a method to sequence microRNAs from specific mouse cell types. EMBO J. 2024 Apr 30. doi: 10.1038/s44318-024-00102-8. PMID: 38689024
Workman RE, Stoltzfus MJ, Keith NC, Euler CW, Bondy-Denomy J, Modell JW. Anti-CRISPR proteins trigger a burst of CRISPR-Cas9 expression that enhances phage defense. Cell Rep. 2024 Mar 26;43(3):113849. doi: 10.1016/j.celrep.2024.113849. Epub 2024 Feb 29. PMID: 38427560; PMCID: PMC11078563. [ link ]
Zhao S, Cordes J, Caban KM, Götz MJ, Mackens-Kiani T, Veltri AJ, Sinha NK, Weickert P, Kaya S, Hewitt G, Nedialkova DD, Fröhlich T, Beckmann R, Buskirk AR, Green R, Stingele J. RNF14-dependent atypical ubiquitylation promotes translation-coupled resolution of RNA-protein crosslinks. Mol Cell. 2023 Dec 7;83(23):4290-4303.e9. doi: 10.1016/j.molcel.2023.10.012. Epub 2023 Nov 10. PMID: 37951216. Link
Coller, J., Ignatova, Z. tRNA therapeutics for genetic diseases. Nat Rev Drug Discov (2023). https://doi.org/10.1038/s41573-023-00829-9
Link
