Recent Publications

Schmidt H, Putnam A, Rasoloson D, Seydoux G. Protein-based condensation mechanisms drive the assembly of RNA-rich P granules. Elife. 2021 Jun 9;10:e63698. doi: 10.7554/eLife.63698. PMID: 34106046; PMCID: PMC8238508. Link

Wang Q, Hernández-Ochoa EO, Viswanathan MC, Blum ID, Do DC, Granger JM, Murphy KR, Wei AC, Aja S, Liu N, Antonescu CM, Florea LD, Talbot CC Jr, Mohr D, Wagner KR, Regot S, Lovering RM, Gao P, Bianchet MA, Wu MN, Cammarato A, Schneider MF, Bever GS, Anderson ME. CaMKII oxidation is a critical performance/disease trade-off acquired at the dawn of vertebrate evolution. Nat Commun. 2021 May 26;12(1):3175. doi: 10.1038/s41467-021-23549-3. PMID: 34039988; PMCID: PMC8155201. Link

Shubin CB, Mayangsari R, Swett AD, Greider CW. Rif1 regulates telomere length through conserved HEAT repeats. Nucleic Acids Res. 2021 Apr 19;49(7):3967-3980. doi: 10.1093/nar/gkab206. PMID: 33772576; PMCID: PMC8053089. Link

Pokrass MJ, Regot S. 3D time-lapse microscopy paired with endpoint lineage analysis in mouse blastocysts. STAR Protoc. 2021 Apr 8;2(2):100446. doi: 10.1016/j.xpro.2021.100446. PMID: 33899025; PMCID: PMC8055709. Link

Clark HR, McKenney C, Livingston NM, Gershman A, Sajjan S, Chan IS, Ewald AJ, Timp W, Wu B, Singh A, Regot S. Epigenetically regulated digital signaling defines epithelial innate immunity at the tissue level. Nat Commun. 2021 Mar
23;12(1):1836. doi: 10.1038/s41467-021-22070-x. PMID: 33758175; PMCID: PMC7988009. Link

Guan R, Lian T, Zhou BR, He E, Wu C, Singleton M, Bai Y. Structural and dynamic mechanisms of CBF3-guided centromeric nucleosome formation. Nat Commun. 2021 Mar 19;12(1):1763. doi: 10.1038/s41467-021-21985-9. PMID: 33741944; PMCID: PMC7979930. Link

Xu Z, Green B, Benoit N, Sobel JD, Schatz MC, Wheelan S, Cormack BP. Cell wall protein variation, break-induced replication, and subtelomere dynamics in Candida glabrata. Mol Microbiol. 2021 Mar 13. doi: 10.1111/mmi.14707. Epub  ahead of print. PMID: 33713372. Link

Research

A natural single-guide RNA repurposes Cas9 to autoregulate CRISPR-Cas expression

Work by RE Workman and T Pammi from the Modell lab:

CRISPR-Cas systems provide their prokaryotic hosts with acquired immunity against viruses...

Multiplexed monitoring to track single cell signaling dynamics

We highlight the research of the Regot Lab:

 

A fundamental property of living cells is their extraordinary ability to sense and...

Scalable and versatile genome editing using linear DNAs with microhomology to Cas9 Sites in Caenorhabditis elegans

Work by Alex Paix from the Seydoux Lab:

"Homology-directed repair (HDR) of double-strand DNA breaks is a promising method for genome...