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Recent Publications
Workman RE, Pammi T, Nguyen BTK, Graeff LW, Smith E, Sebald SM, Stoltzfus MJ, Euler CW, Modell JW. (2021) A natural single guide RNA repurposes Cas9 to autoregulate CRISPR-Cas expression. Cell. 2021 Jan 6:S0092-8674(20)31687-1. doi: 10.1016/j.cell.2020.12.017. Epub ahead of print. PMID: 33421369. [link] [pdf]
Aikin T, Peterson A, Pokrass MJ, Clark HR, Regot S. MAPK Activity Dynamics Regulates Non-Cell Autonomous Effects of Oncogene Expression. (2020) Elife. Sep 17;9:e60541. [link] [pdf]
(2020) Developmental, cellular, and behavioral phenotypes in a mouse model of congenital hypoplasia of the dentate gyrus. Elife. 9:e62766. doi: 10.7554/eLife.62766. PMID: 33084572 [link]
Pinkard O, McFarland S, Sweet T, Coller J. Quantitative tRNA-sequencing uncovers metazoan tissue-specific tRNA regulation. Nature Communications. 2020;11(1):4104. Published 2020 Aug 14. doi:10.1038/s41467-020-17879-x [link]
Schaffer, AE, Pinkard, O., and Coller J (2019). tRNA Metabolism and Neurodevelopmental Disorders. Annual Reviews Genomics Human Genetics. PMID 31082281. [ link ] [ pdf ]
(2020) Structure of the RECK CC domain, an evolutionary anomaly. Proceedings of the National Academy of Sciences of the United States of America.117(26):15104-15111. doi: 10.1073/pnas.2006332117. Epub 2020 Jun 15. PMID: 32541044 [link]
Upcoming Events
Research
A natural single-guide RNA repurposes Cas9 to autoregulate CRISPR-Cas expression
Work by RE Workman and T Pammi from the Modell lab:
CRISPR-Cas systems provide their prokaryotic hosts with acquired immunity against viruses...
Multiplexed monitoring to track single cell signaling dynamics
We highlight the research of the Regot Lab:
A fundamental property of living cells is their extraordinary ability to sense and...
Scalable and versatile genome editing using linear DNAs with microhomology to Cas9 Sites in Caenorhabditis elegans
Work by Alex Paix from the Seydoux Lab:
"Homology-directed repair (HDR) of double-strand DNA breaks is a promising method for genome...