Pinkard O, McFarland S, Sweet T, Coller J. Quantitative tRNA-sequencing uncovers metazoan tissue-specific tRNA regulation. Nature Communications. 2020;11(1):4104. Published 2020 Aug 14. doi:10.1038/s41467-020-17879-x [link]

Schaffer, AE, Pinkard, O., and Coller J (2019). tRNA Metabolism and Neurodevelopmental Disorders. Annual Reviews Genomics Human Genetics. PMID 31082281. [ link ] [ pdf ]

Lee, CY, Putnam, A, Lu T, He S, Ouyang JPT and Seydoux, G. Recruitment of mRNAs to P granules by condensation with intrinsically disordered proteins. Elife. 2020 Jan 24;9:e52896. doi: 10.7554/eLife.52896. [link]

Sabbagh M.F., Nathans J. (2020) A genome-wide view of the de-differentiation of central nervous system endothelial cells in culture. eLife 9:e51276 doi: 10.7554/eLife.51276. [ link ] [ pdf ]

Park, E, Scott, PM, Clutario, KM, Cassidy, KB, Zhan, K, Gerber and Holland, AJ. (2019) WBP11 is required for splicing the TUBGCP6 pre-mRNA to promote centriole duplication. Journal of Cell Biology 219 (1): e201904203. [ link ] [ pdf ]

Mercey, O*, Levine, M.S*, LoMastro, G, Rostaing, P, Brotslaw, E, Gomez, V, Kumar, A, Spassky, N, Mitchell, BJ, Meunier, A* and Holland, AJ.* (2019) Massive centriole production can occur in the absence of deuterosomes in multiciliated cells. Nature Cell Biology 21: 1544-52. (2019). *equal contribution [ link ] [ pdf ]

Alexandre Paix, Dominique Rasoloson, Andrew Folkmann, and Geraldine Seydoux (2019). Rapid Tagging of Human Proteins with Fluorescent Reporters by Genome Engineering using Double-Stranded DNA Donors. Current Protocols in Molecular Biology e102, Volume 129. [ link ]

Heng J.S., Hackett S.F., Stein-O’Brien G.L., Winer B.L., Williams J., Goff L.A., Nathans J. (2019) Comprehensive analysis of a mouse model of spontaneous uveoretinitis using single-cell RNA sequencing. Proceedings of the National Academy of Sciences of the United States of America 116 (52) 26734-26744. [ link ] [ pdf ]

Lee, CY, Putnam, A, Lu T., Seydoux, G 2019. Recruitment of mRNAs to P granules by gelation with intrinsically-disordered proteins. [ pdf ]


Ouyang, JPT, Folkmann, A, Bernard, L, Lee, CY, Seroussi, U, Charlesworth, AG et al. P Granules Protect RNA Interference Genes from Silencing by piRNAs. Dev. Cell. 2019</u>; :. doi: 10.1016/j.devcel.2019.07.026. [ pdf ]

Cable, J, Brangwynne, C, Seydoux, G, Cowburn, D, Pappu, RV, Castañeda, CA et al. Phase separation in biology and disease-a symposium report. Ann. N. Y. Acad. Sci. 2019;1452 (1):3-11. doi: 10.1111/nyas.14126. [ pdf ]

Putnam, A, Cassani, M, Smith, J, Seydoux, G. A gel phase promotes condensation of liquid P granules in Caenorhabditis elegans embryos. Nat. Struct. Mol. Biol. 2019;26 (3):220-226. doi: 10.1038/s41594-019-0193-2. [ pdf ]

Folkmann, AW, Seydoux, G. Spatial regulation of the polarity kinase PAR-1 by parallel inhibitory mechanisms. Development. 2019;146 (6):. doi: 10.1242/dev.171116. [ pdf ]

Lee, CY, Seydoux, G. Dynamics of mRNA entry into stress granules. Nat. Cell Biol. 2019;21 (2):116-117. doi: 10.1038/s41556-019-0278-5. [ pdf ]

Paix A, Rasoloson D, Folkman A, Seydoux G. (2019) Rapid Tagging of Human Proteins with Fluorescent Reporters by Genome Engineering using Double‐Stranded DNA Donors. Current Protocols in Molecular Biology Volume 129, e102. doi: 10.1002/cpmb.102 [ link ]

Rattner A., Williams J., Nathans J. (2019) Roles of HIFs and VEGF in angiogenesis in the retina and brain. The Journal of Clinical Investigation 129 (9):3807-3820. [ link ] [ pdf ]

Pike AM, Strong MA, Ouyang JPT, Greider CW. (2019) TIN2 functions with TPP1/POT1 to stimulate telomerase processivity. American Society for Microbiology ASM:doi:[ link ] [ pdf ]

Peng X, Williams J, Smallwood PM, Nathans J. (2019) Defining the binding interface of Amyloid Precursor Protein (APP) and Contactin3 (CNTN3) by site-directed mutagenesis. PLoS ONE 14(7):e0219384. [ link ] [ pdf ]

Cho, C., Wang, Y., Smallwood, P.M., Williams, J., Nathans, J. (2019) Molecular determinants in Frizzled, Reck, and Wnt7a for ligand-specific signaling in neurovascular development.  eLife 8: e47300. [ pdf ]

D’Orazio KN, Wu CC, Sinha NK, Loll-Krippleber R, Brown GW, Green R. (2019) The endonuclease Cue2 cleaves mRNAs at stalled ribosomes during No Go Decay. eLife 2019;8:e49117 doi: 10.7554/eLife.49117 [ link ] [ pdf ]

Kearse MG, Goldman DH, Choi J, Nwaezeapu C, Liang D, Green KM, Goldstrohm AC, Todd PK, Green R, Wilusz JE. (2019) Ribosome queuing enables non-AUG translation to be resistant to multiple protein synthesis inhibitors. Genes and Development 33: 871-885. [ link ] [ pdf ]

Moyer TC, Holland AJ. (2019) PLK4 promotes centriole duplication by phosphorylating STIL to link the procentriole to the microtubule wall. eLife 8: e46054. [ link ] [ pdf ]


Cho C., Wang Y., Smallwood P.M., Williams J., Nathans J. (2019) Dlg1 activates beta-catenin signaling to regulate retinal angiogenesis and the blood-retina and blood-brain barriers. eLife 2019;8:e45542 doi: 10.7554/eLife.45542. [ link ] [ pdf ]

LoMastro GM, Holland AJ. (2019) The emerging link between centrosome aberrations and metastasis. Developmental Cell 49(3): 325-31. (2019). [ link ] [ pdf ]

DeFelice MM, Clark HR, Hughey JJ, Maayan I, Kudo T, Gutschow MV, Covert MW, Regot S. (2019) NF-κB signaling dynamics is controlled by a dose-sensing autoregulatory loop. Science Signaling. 12(579). pii: eaau3568. doi: 10.1126/scisignal.aau3568. [ link ] [ pdf ]

Wang, Y, Sabbagh, MF,  Gu, X, Rattner, A, Williams, J, and Nathans, J. (2019) Beta-catenin signaling regu lates barrier-specific gene expression in circumventricular organ and ocular vasculatures.  eLife 8: e43257. [ pdf ]

Heng, J.S., Rattner, A., Stein-O’Brien, G.L., Winer, B.L., Jones, B.W., Vernon, H.J., Goff, L.A., and Nathans, J . (2019)  Hypoxia tolerance in the Norrin-deficient retina and the chronically hypoxic brain studied at single-cell resolution. Proceedings of the National Academy of Sciences USA  116:9103-9114. [ pdf ]

Seth, P., Hsieh, P., Jamal, S., Wang, L., Gygi, S., Jain, M., Coller, J., and Stamler, J. (2019). Regulation of MicroRNA Machinery and Development by Interspecies S-Nitrosylation. Cell, 146:1014-1025. [link]

Mohammad F, Green R, Buskirk AR. (2019)  A systematically-revised ribosome profiling method for bacteria reveals pauses at single-codon resolution. Elife. 2019 Feb 6;8. pii: e42591. [ link ]

Wu CC, Zinshteyn B, Wehner KA, Green R. (2019) High-Resolution Ribosome Profiling Defines Discrete Ribosome Elongation States and Translational Regulation during Cellular Stress. Mol Cell. 2019 Jan 11. pii: S1097-2765(18)31063-3. [ link ]

Zinshteyn B, Chan D, England W, Feng C, Green R, Spitale RC. (2019) Assaying RNA structure with LASER-Seq. Nucleic Acids Res. 2019 Jan 10;47(1):43-55. [ link ]

Corden JL.  (2019)  An Arginine Nexus in the RNA Polymerase II CTD. Mol Cell. 2019 Jan 3;73(1):3-4. [ link ]

Breslow DK, Holland AJ. (2019) Mechanism and regulation of centriole and cilium biogenesis. Annual Review of Biochemistry. 88: 691-724. [ link ] [ pdf ]

Kreutzberger A, Ji M, Aaron J, Mihaljevic LjUrban S. (2019) Rhomboid distorts lipids to break the viscosity-imposed speed limit of membrane diffusion. Science 363(6426):497 [ link ] [ pdf ]

Mugridge, J.S., Coller, J., and Gross, J., (2018). Structural and molecular mechanisms for the control of 5′ – 3′ mRNA decay. Nature Structural and Molecular Biology, 25:1077-1085. [link]

Arango, D., Sturgill, D., Alhusaini, N., Dillman, A., Sweet, T., Hanson, G., Sinclair, W., Hosogane, M., Nanan, K., Fox,S., Zengeya, T., Andresson,T., Meier, J., Coller, J., and Oberdoerffer, S. (2018). Acetylation of cytidine in messenger RNA promotes translation efficiency. Cell, 175:1872-1886. [link]

Wang, Y., Cho, C., Williams, J., Smallwood, P.M., Zhang, C.,  Junge, H.J., and Nathans, J. (2018) Interplay of the Norrin and Wnt7a/Wnt7b signaling systems in blood-brain barrier and blood-retina barrier development and maintenance. Proceedings of the National Academy of Sciences USA 15: E11827-E11836. [ pdf ]

Hanson, G., Alhusaini, N., Sweet, TJ., and Coller, J. (2018). Ribosomal A-site decoding is an important determinant of mRNA stability, RNA, 24:1377-1389 [link]

Peng, X., Emiliani, F., Smallwood, P.M., Rattner, A., Lei, H., Sabbagh, M.F., and Nathans, J.  (2018) Affinity capture of polyribosomes followed by RNAseq (ACAPseq), a discovery platform for protein-protein interactions.  eLife 7: e40982. [ pdf ]

Sabbagh, M.F., Heng, J.S., Luo, C., Castanon, R.G., Nery, J.R., Rattner, A., Goff, L.A., Ecker, J.R., Nathans, J. (2018) Transcriptional and epigenomic landscapes of CNS and non-CNS vascular endothelial cells. eLife 7: e36187 [ pdf ]

Wagner CL, Hanumanthu VS, Talbot CC Jr, Abraham RS, Hamm D, Gable DL, Kanakry CG, Applegate CD, Siliciano J, Jackson JB, Desiderio S, Alder JK, Luznik L, Armanios M. (2018) Short telomere syndromes cause a primary T cell immunodeficiency. J Clin Invest. 2018 Dec 3;128(12):5222-5234. [ link ]

Luo J, Sun X, Cormack BP, Boeke JD. (2018) Karyotype engineering by chromosome fusion leads to reproductive isolation in yeast. Nature. 2018 Aug;560(7718):392-396. [ link ]

Burow, D., Martin, S., Quail, J., Alhusaini, N., Coller, J., and Cleary, M. (2018). Attenuated codon optimality contributes to neural-specific mRNA decay in Drosophila. Cell Reports, 24,1704-1712. [link]

Ward A, Kumari G, Sen R, Desiderio S. (2018) The RAG-2 Inhibitory Domain Gates Accessibility Of The V(D)J Recombinase To Chromatin. Mol Cell Biol. 2018 May 14. pii: MCB.00159-18. [ link ]

Webster, MW, Chen, YH, Stowell, J, Alhusaini, N, Sweet, T, Graveley, B, Coller, J*. and Passmore, L.* (2018). mRNA Deadenylation Is Coupled to Translation Rates by the Differential Activities of Ccr4-Not Nucleases. Molecular Cell, 70,1089 – 1100. *co-corresponding authors [link]

Levine, M.S., Holland, A.J. (2018) The impact of mitotic errors on cell proliferation and tumorigenesis. Genes and Development 32(9-10): 620-38. [ link ] [ pdf ]

Coller, J. and Grayhack, E.J. (2018). The analysis of translational mechanisms that modulate gene expression. Methods 137; 1-98.[link]

Jonathan K. Alder, Vidya Sagar Hanumanthu, Margaret A. Strong, Amy E. DeZern, Susan E. Stanley, Clifford M. Takemoto, Ludmilla Danilova, Carolyn D. Applegate, Stephen G. Bolton, David W. Mohr, Robert A. Brodsky, James F. Casella, Carol W. Greider, J. Brooks Jackson and Mary Armanios. (2018) Diagnostic utility of telomere length testing in a hospital-based setting. PNAS 115 (10): E2358-E2365 [ link ] [ pdf ]

Chen, H., Xue, J., Churikov, D., Hass, E.P., Lemon, L.D., Luciano, P., Bertuch, A.A., Zappulla, D.C., Geli, V., Wu, J., and Lei.M. (2018) Structural insights into yeast telomerase telomerase recruitment to telomeres. Cell 172:331–343 [ link ]

Hass, E.P. and Zappulla, D.C. (2017) A yeast two-hybrid system based on CRISPR-dCas9 for investigating RNA-protein interactions. bioRxiv doi:

 [ link ] 

Nigg, E.A., Holland, A.J. (2018) Once and only once: mechanisms of centriole duplication and their deregulation in disease. Nature Reviews Molecular Cell Biology 19(5): 297-312. [ link ] [ pdf ]

Lu W, Dordai D, Huso D, Desiderio S. (2018) Smoothened signaling in the mouse osteoblastoid lineage is required for efficient B lymphopoiesis. Blood. 2018 Jan 18;131(3):323-327. [ link ]

Chang, H., Smallwood, P.M., Williams, J., and Nathans, J. (2017) Intramembrane proteolysis of Astrotactins.  Journal of Biological Chemistry 292: 3506-3516. [ pdf ]

Goldberg, GW, McMillan EA, Varble A, Modell JW, et al. (2018) Incomplete prophage tolerance by type III-A CRISPR-Cas systems reduces the fitness of lysogenic hosts. Nat Commun. 9(1):61. [ link ] [ pdf ]

Lima, S. A., Chipman, L. B., Nicholson, A. L., Chen, Y.-H., Yee, B. A., Yeo, G. W., et al. (2017). Short poly(A) tails are a conserved feature of highly expressed genes. Nature Structural & Molecular Biology, 64, e4019. [link]

Kudo T, Jeknić S, Macklin DN, Akhter S, Hughey JJ, Regot S, Covert MW. (2018) Live-cell measurements of kinase activity in single cells using translocation reporters. Nature Protocols 13(1):155-169. doi: 10.1038/nprot.2017.128. [ link ] [ pdf ]

Paix A, Folkmann A, Goldman DH, Kulaga H, Grzelak MJ, Rasoloson D, Paidemarry S, Green R, Reed RR, Seydoux G. (2017) Precision genome editing using synthesis-dependent repair of Cas9-induced DNA breaks. Proc Natl Acad Sci U S A. (2017) Dec 12;114(50):E10745-E10754.[ link ]

Yoon KJ, Ringeling FR, Vissers C, Jacob F, Pokrass M, Jimenez-Cyrus D, Su Y, Kim NS, Zhu Y, Zheng L, Kim S, Wang X, Doré LC, Jin P, Regot S, Zhuang X, Canzar S, He C, Ming GL, Song H. (2017) Temporal Control of Mammalian Cortical Neurogenesis by m6A Methylation. Cell 171(4):877-889.e17. [ link ] [ pdf ]

Xiao H, Wang F, Wisniewski J, Shaytan AK, Ghirlando R, Fitzgerald P, Huang Y, Wei D, Li S, Landsman D, Panchenko AR, Wu C. Molecular basis of CENP-C association with the CENP-A nucleosome at yeast centromeres. Genes Dev. Oct 26 Epub ahead of print, PMID 29074736 (2017). [ link ]

Hanson, G., & Coller, J. (2018). Codon optimality, bias and usage in translation and mRNA decay. Nature Reviews Molecular Cell Biology, 19:20-30 [link]

Mok CA, Au V, Thompson OA, Edgley ML, Gevirtzman L, Yochem J, Lowry J, Memar N, Wallenfang MR, Rasoloson D, Bowerman B, Schnabel R, Seydoux G, Moerman DG, Waterston RH. (2017) MIP-MAP: High-Throughput Mapping of Caenorhabditis elegans Temperature-Sensitive Mutants via Molecular Inversion Probes. Genetics Oct;207(2):447-463. [ link ]

Shaytan AK, Xiao H, Armeev GA, Wu C, Landsman D, Panchenko AR. (2017) Hydroxyl-radical footprinting combined with molecular modeling identifies unique features of DNA conformation and nucleosome positioning. Nucleic Acids Res. Sep 19; 45(16):9229-9243, PMID 28934480. [ link ] [ pdf ]

Merran J, Corden JL. (2017) Yeast RNA-Binding Protein Nab3 Regulates Genes Involved in Nitrogen Metabolism. Mol Cell Biol. 2017 Aug 28;37(18). [ link ]

Wang, S., Pike, A. M., Lee, S. S., Strong, M.A., Connelly, C.J., Greider, C.W. (2017) BRD4 inhibitors block telomere elongation. Nucleic Acids Research. 45(14): 8403-8410. [ link ] [ pdf ]

Claire de la Cova, Robert Townley, Sergi Regot, Iva Greenwald. (2017). A Real-Time Biosensor for ERK Activity Reveals Signaling Dynamics during C. elegans Cell Fate Specification. Developmental Cell DOI: [ link ] [ pdf ]

Cho, C., Smallwood, P.M., Nathans, J. (2017) Reck and Gpr124 Are Essential Receptor Cofactors for Wnt7a/Wnt7b-Specific Signaling in Mammalian CNS Angiogenesis and Blood-Brain Barrier Regulation. Neuron 95 (5): 1056-1076 [ pdf ]

Modell JW, Jiang W, Marraffini LA. (2017) CRISPR-Cas systems exploit viral DNA injection to establish and maintain adaptive immunity. Nature 544(7648):101-104. [ link ] [ pdf ]

Bettridge J, Na CH, Pandey A, Desiderio S. (2017) H3K4me3 induces allosteric conformational changes in the DNA-binding and catalytic regions of the V(D)J recombinase. Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):1904-1909. [ link ]

Levine, M.S., Bakker, B., Boeckx, B., Moyett, J., Lu, J., Vitre, B., Spierings, D.C., Lansdorp, P.M., Cleveland, D.W., Lambrechts, D., Foijer, F. and Holland, A.J. (2017) Centrosome Amplification Is Sufficient to Promote Spontaneous Tumorigenesis in Mammals. Developmental Cell 40(3): 313-22. (2017). [ link ] [ pdf ]

Urban S. (2016) Cartography of intramembrane proteolysis. Cell 167(7):1898. [ link ] [ pdf ]

Smith J, Calidas D, Schmidt H, Lu T, Rasoloson D, Seydoux G. (2016) Spatial patterning of P granules by RNA-induced phase separation of the intrinsically-disordered protein MEG-3. eLife 2016;10.7554/eLife.21337. [ link ]

Wang, Y., Chang, H., Rattner, A., and Nathans, J. (2016) Frizzled receptors in development and disease. Current Topics in Developmental Biology 117: 113-139. [ pdf ]

Wang, Y., Williams, J., Rattner, A., Wu, S., Bassuk, A.G., Goffinet, A.M., and Nathans, J. (2016) Patterning of papillae on the mouse tongue: A system for the quantitative assessment of planar cell polarity signaling.  Developmental Biology 419: 298-310. [ pdf ]

Wang F, Ranjan A, Wei D, Wu C. (2016) Comment on “A histone acetylation switch regulates H2A.Z deposition by the SWR-C remodeling enzyme”. Science 353(6297):358, PMID: 27463665. [ pdf ]

Lambrus, B.G., Daggubati, V., Uetake, Y., Scott, P.M., Clutario, K.M., Sluder, G., Holland, A.J. (2016) A USP28-53BP1-p53-p21 signaling axis arrests growth following centrosome loss or prolonged mitosis. Journal of Cell Biology 214:143-153. [ link ] [ pdf ]

Greider, C.W. (2016) Regulating telomere length from the inside out: the replication fork model. Genes & Development 30(13):1483-1491. [ pdf ]

Nathans, J. and Sterling, P. (2016) How scientists can reduce their carbon footprint. eLife 5: e15928. [ pdf ]

Liang X, Shan S, Pan L, Zhao J, Ranjan A, Wang F, Zhang Z, Huang Y, Feng H, Wei D, Huang L, Liu X, Zhong Q, Lou J, Li G, Wu C, Zhou, Z. (2016) Structural basis of H2A.Z recognition by SRCAP chromatin remodelling subunit YL1. Nat Struct Mol Biol. 23(4):317-23. Epub Mar 14. [ pdf ]

Mo, A., Luo, C., Davis, F.P., Mukamel, E.A., Henry, G.L., Nery, J.R., Urich, M.A., Picard, S., Lister, R., Eddy, S.R., Beer, M.A., Ecker, J.R., and Nathans, J. (2016) Epigenomic landscapes of retinal rods and cones. eLife 5: e11613. [ pdf ]

Liu B, Zheng Y, Yin F, Yu J, Silverman N, Pan D. (2016) Toll Receptor-Mediated Hippo Signaling Controls Innate Immunity in Drosophila. Cell, 36: 246-248. [ pdf ]

Desiderio S. (2016) Pumping the breaks on B cell development. J Exp Med. 2016 Feb 8;213(2):140. [ link ]

Hong J, Feng H, Wang F, Ranjan A, Chen J, Jiang J, Ghirlando R, Xiao TS, Wu C, Bai Y. (2014) The Catalytic Subunit of the SWR1 Remodeler Is a Histone Chaperone for the H2A.Z-H2B Dimer. Mol Cell. 53:498-505. [ pdf ]

Cho S, Dickey SW, Urban S. (2016) Crystal Structures and Inhibition Kinetics Reveal a Two-Stage Catalytic Mechanism with Drug Design Implications for Rhomboid Proteolysis. Molecular Cell 61(3):329-40. [ link ] [ pdf ]

Niederer, R.O., Papadopoulos, N., and Zappulla, D.C. (2016) Identification of novel noncoding transcripts in telomerase-negative yeast using RNA-seq. Scientific Reports 6, 19376; doi: [ link ]

Abrahamsson S, Ilic R, Wisniewski J, Mehl B, Yu L, Chen L, Davanco M, Oudjedi L, Fiche J, Hajj B, Jin X, Pulupa J, Cho C, Mir M, El Beheiry M, Darzacq X, Nollmann M, Dahan M, Wu C, Lionnet T, Liddle A, Bargmann C. (2016) Multifocus microscopy with precise color multi-phase diffractive optics applied in functional neuronal imaging. Biomedical Optics Express 7(3):855-869. [ pdf ]

Lee, S, S., Bohrson, C. Pike, A.M., Whellan, S.J., and Greider, C.W. (2015) ATM kinase is required for telomere elongation in mouse and human cells. Cell Reports 13(8):1623-1632. [ pdf ]

Chang, H., Smallwood, P.M., Williams, J., and Nathans, J. (2016) The spatio-temporal domains of Frizzled6 action in planar polarity control of hair follicle orientation. Developmental Biology 409: 181-193. [ pdf ]

Paix A, Folkmann A, Rasoloson D, Seydoux G. (2015) High Efficiency, Homology-Directed Genome Editing in Caenorhabditis elegans Using CRISPR-Cas9 Ribonucleoprotein Complexes. Genetics 201(1):47-54. [ pdf ]

Sun GJ, Zhou Y, Stadel RP, Moss J, Yong JH, Ito S, Kawasaki NK, Phan AT, Oh JH, Modak N, Reed RR, Toni N, Song H, Ming GL. (2015) Tangential migration of neuronal precursors of glutamatergic neurons in the adult mammalian brain. Proceedings of the National Academy of Sciences USA 112(30):9484-9. [ pdf ]

Buhr ED, Yue WW, Ren X, Jiang Z, Liao HW, Mei X, Vemaraju S, Nguyen MT, Reed RR, Lang RA, Yau KW, Van Gelder RN. Neuropsin (OPN5)-mediated photoentrainment of local circadian oscillators in mammalian retina and cornea. (2015) Proceedings of the National Academy of Sciences USA. 112(42):13093-8. [ pdf ]

DiGirolamo DJ, Singhal V, Chang X, Lee SJ, Germain-Lee EL. (2015) Administration of soluble activin receptor 2B increases bone and muscle mass in a mouse model of osteogenesis imperfecta. Bone Research Feb 10;3:14042.  [ pdf ]

Lee YS, Lehar A, Sebald S, Liu M, Swaggart KA, Talbot CC Jr, Pytel P, Barton ER, McNally EM, Lee SJ. (2015) Muscle hypertrophy induced by myostatin inhibition accelerates degeneration in dysferlinopathy. Human Molecular Genetics 24:(20):5711-9. 

  [ pdf ]

Se-Jin Lee, Suzi Sebald

Zheng Y, Wang W, Liu B, Deng H, Uster E, and Pan D. (2015) Identification of Happyhour/MAP4K as alternative Hpo/Mst-like kinases in the Hippo kinase cascade. Developmental Cell, 34: 642-655. [ link ] [ pdf ]

Cai, J., Maitra, A., Anders, R.A., Taketo, M.M., and Pan, D. (2015) beta-Catenin destruction complex-independent regulation of Hippo-YAP signaling by APC in intestinal tumorigenesis. Genes & Devopment., 29: 1493-1506. [ pdf ]

Chen Q, Zhang, N., Xie R, Wang W, Cai J, Choi KS, David KK, Huang B, Yabuta N, Nojima H, and Pan D. (2015) Homeostatic control of Hippo signaling activity revealed by an endogenous activating mutation in YAP. Genes & Development., 29: 1285-1297. [ pdf ]

Deng H, Wang W, Yu J, Zheng Y, Qing Y, and Pan D. (2015) Spectrin regulates Hippo signaling by modulating cortical actomyosin activity. eLife, Mar 31:e06567. doi: 10.7554/eLife.06567. [ pdf ]

Mefford, M.A. and Zappulla, D.C. (2016) Physical connectivity mapping by circular permutation of human telomerase RNA reveals new regions critical for activity and processivity. Molecular and Cellular Biology 36:251–261. [ link ]

Kaizer H, Connelly CJ, Bettridge K, Viggiani C, Greider CW. (2015) Regulation of Telomere Length Requires a Conserved N-Terminal Domain of Rif2 in Saccharomyces cerevisiae. Genetics 201:573-586. [ pdf ]

Koutmou KS, Schuller AP, Brunelle JL, Radhakrishnan A, Djuranovic S, Green R. (2015) Ribosomes slide on lysine-encoding homopolymeric A stretches. Elife 4 doi: 10.7554/eLife.05534. [ pdf ]

Woolstenhulme CJ, Guydosh NR, Green R, Buskirk AR. (2015) High-precision analysis of translational pausing by ribosome profiling in bacteria lacking EFP. Cell Reports 11(1):13-21. [ pdf ]

Kowalinski E, Schuller A, Green R, Conti E. (2015) Saccharomyces cerevisiae Ski7 Is a GTP-Binding Protein Adopting the Characteristic Conformation of Active Translational GTPases. Structure 23(7):1336-43.[ pdf ]

Young DJ, Guydosh NR, Zhang F, Hinnebusch AG, Green R. (2015) Rli1/ABCE1 Recycles Terminating Ribosomes and Controls Translation Reinitiation in 3’UTRs In Vivo. Cell 162(4):872-84. [ pdf ]

Arthur L, Pavlovic-Djuranovic S, Smith-Koutmou K, Green R, Szczesny P, Djuranovic S. (2015) Translational control by lysine-encoding A-rich sequences. Science Advances 1(6): soi:10.1126/sciadv. 1500154.  [ pdf ]

Lu C, Ward A, Bettridge J, Liu Y, Desiderio S. (2015) An autoregulatory mechanism imposes allosteric control on the V(D)J recombinase by histone H3 methylation. Cell Reports 10(1): 29-38.  [ pdf ]

Zordan RE, Beliveau BJ, Trow JA, Craig NL, Cormack BP. (2015) Avoiding the ends: internal epitope tagging of proteins using transposon Tn7. Genetics 200(1):47-58.[ pdf ]

Li CX, Gleason JE, Zhang SX, Bruno VM, Cormack BP, Culotta VC. (2015) Candida albicans adapts to host copper during infection by swapping metal cofactors for superoxide dismutase. Proceedings of the National Academy of Sciences USA 112:38, E5336-E5342. [ pdf ]

Chang, H., Cahill, H., Smallwood, P.M., Wang, Y., and Nathans, J. (2015) Identification of Astrotactin2 as a genetic modifier that regulates the global orientation of mammalian hair follicles. PLOS Genetics 11: e1005532. [ pdf ]

Hass, E. and Zappulla, D.C. (2015) The Ku subunit of telomerase binds Sir4 to recruit telomerase to lengthen telomeres in S. cerevisiae. eLIFE 2015; 10.7554/eLife.07750 [ link ]

Lambrus BG, Uetake Y, Clutario KM, Daggubati V, Snyder M, Sluder G, Holland AJ. (2015) p53 protects against genome instability following centriole duplication failure. Journal of Cell Biology 210(1), 63-77. [ pdf ]

Baker RP, Urban S. (2015) Cytosolic extensions directly regulate a rhomboid protease by modulating substrate gating. Nature 523, 101–105. [ link ]

Ranjan A, Wang F, Wei D, Huang Y, Wu C. (2015) Nucleosome H2A histone fold and DNA elements activate SWR1-mediated H2A.Z replacement. eLIFE June 27. [ pdf ]

Moyer TC, Clutario KM, Lambrus BG, Daggubati V, Holland AJ. (2015) STIL binding to Plk4 activates kinase activity to promote centriole duplication. Journal of Cell Biology. 209(6), 863-78. [ pdf ]

Mo, A., Mukamel, E.A., Davis, F.P., Luo, C., Henry, G.L., Picard, S., Urich, M.A., Nery, J.R., Sejnowski, T.J., Lister, R., Eddy, S.R., Ecker, J.R., and Nathans, J. (2015) Epigenomic signatures of neuronal diversity in the mammalian brain. Neuron 86:1369-1384. [ pdf ]

Kim J, Duan R, Jin P, Chen EH. (2015) Mechanisms of myoblast fusion during muscle development. Current Opinion in Genetics and Development. 32, 162-170. [ pdf ]

Heler R*, Samai P*, Modell JW, Weiner C, Goldberg GW, Bikard D, Marraffini LA. (2015) Cas9 specifies functional viral targets during CRISPR-Cas adaptation. Nature. 519(7542):199-202. [ link ] [ pdf ]

Kim JH, Ren Y, Ng WP, Li S, Son S, Kee Y, Zhang S, Zhang G, Fletcher DA, Robinson DN, Chen EH. (2015) Mechanical tension drives cell membrane fusion. Developmental Cell 32, 561-73. [ pdf ]

Lebo, K.J., Niederer, R.O., and Zappulla, D.C. (2015) A second essential function of the Est1-binding arm of yeast telomerase RNA. RNA 21:862–76. [ link ]

Wang JT, Smith J, Chen BC, Schmidt H, Rasoloson D, Paix A, Lambrus BG, Calidas D, Betzig E, Seydoux G. (2014) Regulation of RNA granule dynamics by phosphorylation of serine-rich, intrinsically disordered proteins in C. elegans. Elife Dec 23;3:e04591. [ link ]

Niederer, R.O. and Zappulla, D.C. (2015) Refined secondary structure models of the core of yeast and human telomerase RNAs directed by SHAPE. RNA 21:254–261. [ link ]

Hajj B, Wisniewski J, El Beheiry M, Chen J, Revyakin A, Wu C, Dahan M. (2014) Whole-cell, multicolor super-resolution imaging using volumetric multifocus microscopy. Proc Natl Acad Sci U S A. 111:17480-5. [ pdf ]

Modell JW, Kambara TK, Laub MT. (2014) A dna damage-induced, SOS-independent checkpoint prevents cell division in Caulobacter crescentus. PLoS Biology. 12(10):e1001977. [ link ] [ pdf ]

Chen M, Tian S, Yang X, Lane AP, Reed RR, Liu H. (2014) Wnt-responsive Lgr5⁺ globose basal cells function as multipotent olfactory epithelium progenitor cells. Journal of J Neurosci. 34(24):8268-76. [ pdf ]

Qing Y, Yin F, Wang W, Zheng Y, Guo P, Schozer F, Deng H, and Pan D. (2014) The Hippo effector Yorkie activates transcription by interacting with a histone methyltransferase complex through Ncoa6. eLife, Jul 15:e02564. doi: 10.7554/eLife.02564. [ pdf ]

Chen Q, Zhang N, Gray RS, Li H, Ewald AJ, Zahnow CA, and Pan D. (2014) A temporal requirement for Hippo signaling in mammary gland differentiation, growth, and tumorigenesis. Genes & Development., 28: 432-437. [ pdf ]

Urban S, Moin SM. (2014) A subset of membrane-altering agents and gamma-secretase modulators provoke nonsubstrate cleavage by rhomboid proteases. Cell Reports 8, 1241–1247. [ link ]

Hickman AB, Ewis HE, Li X, Knapp JA, Laver T, Doss A-L, Tolun G, Steven AC, Grishaev A, Bax A, Atkinson PW, Craig NL, Dyda F. (2014) Structural basis of hAT transposon end recognition by Hermes, an octameric DNA transposase from Musca domestica. Cell 158, 353–367. [ link ] [ pdf ]

Regot S, Hughey JJ, Bajar BT, Carrasco S, Covert MW. (2014) High-sensitivity measurements of multiple kinase activities in live single cells. Cell 157(7):1724-34. [ link ]

Koutmou KS, McDonald ME, Brunelle JL, Green R. (2014) RF3:GTP promotes rapid dissociation of the class 1 termination factor. RNA May;20(5):609-20. [ link ]

Macia J*, Regot S*, Peeters T, Conde N, Solé R, Posas F. (2009) Dynamic signaling in the Hog1 MAPK pathway relies on high basal signal transduction. Science Signaling Mar 24;2(63):ra13. [ link ]

Wisniewski J, Hajj B, Chen J, Mizuguchi G, Xiao H, Wei D, Dahan M, Wu C. (2014) Imaging the fate of histone Cse4 reveals de novo replacement in S phase and subsequent stable residence at centromeres. eLIFE May 20. [ pdf ]

Guydosh NR, Green R. (2014) Dom34 rescues ribosomes in 3′ untranslated regions. Cell Feb 27;156(5):950-62. [ link ]

Zaher HS, Green R. (2014) In vitro synthesis of proteins in bacterial extracts. Methods in Enzymology 539:3-15. [ link ]

Dickey WS, Baker RP, Cho S, Urban S. (2013) Proteolysis inside the membrane is a rate-governed reaction not driven by substrate affinity. Cell 155, 1270–1281. [ pdf ]

Kwon I, Kato M, Xiang S, Wu L, Theodoropoulos P, Mirzaei H, Han T, Xie S, Corden JL, McKnight SL. (2013) Phosphorylation-regulated binding of RNA polymerase II to fibrous polymers of low-complexity domains. Cell 155, 1049-1060. [ link ]

Yin F, Yu J, Zheng Y, Chen Q, Zhang N, and Pan D. (2013) Spatial organization of Hippo signaling at the plasma membrane mediated by the tumor suppressor Merlin/NF2. Cell (154): 1342-1355. [ pdf ]

Koontz LM, Liu-Chittenden Y, Yin F, Zheng Y, Yu J, Huang B, Chen Q, Wu S, Pan D. (2013) The Hippo effector Yorkie controls normal tissue growth by antagnozing scalloped-mediated default repression. Developmental Cell 25(4):388-401. [ link ] [ pdf ]

Shilagardi K, Li S, Luo F, Marikar F, Duan R, Jin P, Kim J, Murnen K, Chen EH. (2013) Actin-propelled invasive membrane protrusions promote fusogenic protein engagement during cell-cell fusion. Science 340(6130):359-363. [ link ]

Wright JA, Smith RC, Li X, Craig NL, Atkinson PW. (2013) IPB7 transposase behavior in Drosophila melanogaster and Aedes aegypti. Insect Biochemistry and Molecular Biology 43:899-906. [ link ]

Guo Y, Park JM, Cui B, Humes E, Gangadharan S, Hung S, FitzGerald PC, Hoe KL, Grewal SIS, Craig NL, Levin HL. (2013) Profiles of transposon integration detect nucleosome arrays and identify the essential genes of Schizosaccharomyces pombe. Genetics 195(2):599-609. [ link ]

Sharma T, Reed RR. (2013). Balancing Survival: The role of CTGF in controlling experience-modulated olfactory circuitry. Neuron 79(6), 1037-1039. [ pdf ]

Corden JL. (2013) RNA polymerase II C-terminal domain: Tethering transcription to transcript and template. Chemical Reviews 113, 8423-8455. [ link ]

Nguyen VQRanjan A, Stengel F, Wei D, Aebersold R, Wu C, Leschziner AE. (2013) Molecular Architecture of the ATP-Dependent Chromatin-Remodeling Complex SWR1. Cell 154:1220-31. [ pdf ]

Ranjan AMizuguchi G, Fitzgerald PC, Wei D, Wang F, Huang Y, Luk E, Woodcock CL, Wu C. (2013) Nucleosome-free Region Dominates Histone Acetylation in Targeting SWR1 to Promoters for H2A.Z Replacement. Cell 154:1232-45. [ pdf ]

Kaneko-Gogo T, Sato Y, Katada S, Kinameri E, Yoshihara S, Nishiyori A, Kimura M, Fujita H, Touhara K, Reed RR, Yoshihara, Y. (2013) Goofy coordinates the acuity of olfactory signaling. The Journal of Neuroscience 33(32), 2987-12996. [ pdf ]

Lee Y-S, Lee S-J. (2013) Regulation of GDF-11 and myostatin activity by GASP-1 and GASP-2. Proceedings of the National Academy of Sciences USA 110, E3713–22. [ link ]

Li X, Burnight ER, Cooney AL, Malani N, Brady T, Sander JD, Staber J, Wheelan S, Joung JK, McCray PB, Bushman FD, Sinn PL, Craig NL. (2013) piggyBac transposase tools for genome engineering. Proceedings of the National Academy of Sciences USA 110(25):E2279-E2287. [ link ]

Choi KY, Li Y, Sarnovsky R, Craig NL. (2013) Direct interaction between the TnsA and TnsB subunits controls the heteromeric Tn7 transposase. Proceedings of the National Academy of Sciences USA 110(22):E2038-E2045. [ link ]

Rajakumari S, Wu J, Ishibashi, J, Lim HW, Giang AH, Won KJ, Reed RR, Seale P. (2013) EBF2 determines and maintains brown adipocyte identity. Cell Metabolism 17(4), 562-574. [ pdf ]

Seydoux G. (2013) ‘Goldilocks’ suppressor screen identifies web of polarity regulators. Nature Cell Biology 15(1):9-10. [ link ] [ pdf ]

Wang JT, Seydoux G. (2013) Germ cell specification. Advances in Experimental Medicine and Biology 757:17-39. [ pdf ]

Motegi F, Seydoux G. (2013) The PAR network: redundancy and robustness in a symmetry breaking system. Philosophical Transactions of the Royal Society 368(1629):2013. [ pdf ]

He SL, Green R. (2013) Polysome analysis of mammalian cells. Methods in Enzymology 530:183-92. [ link ]

Holland AJ, Fachinetti D, Zhu Q, Bauer M, Verma IM, Nigg EA, Cleveland DW. (2012) The autoregulated instability of Polo-like kinase 4 limits centrosome duplication to once per cell cycle. Genes and Development 26, 2684-2689. [ link ]

Holland AJ*, Fachinetti D*, Cleveland DW. (2012) An inducible system for the rapid and complete destruction of proteins in mammalian cells. Proceedings of the National Academy of Sciences USA 109, E3350-E3357. [ link ]

Holland AJ, Cleveland DW. (2012) The deubiquitinase USP44 is a tumor suppressor that protects against chromosome missegregation. Journal of Clinical Investigation 122, 4325-4328. [ link ]

Holland AJ, Cleveland DW. (2012) Chromoanagenesis and cancer: mechanisms and consequences of localized, complex chromosomal rearrangements. Nature Medicine 18, 1630-1638. [ link ]

Moin SM, Urban S. (2012) Membrane immersion allows rhomboid proteases to achieve specificity by reading transmembrane segment dynamics. Elife 1, e00173. [ link ]

Liu-Chittenden Y, Huang B, Shim JS, Chen Q, Lee S-J, Anders RA, Liu JO, Pan D. (2012) Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP. Genes & Development 26, 1300–1305. [ link ] [ pdf ]

Sebé-Pedrós A, Zheng Y, Ruiz-Trillo I, and Pan D. (2012) Premetazoan origin of the Hippo signaling pathway. Cell Reports, (1): 13-20. [ pdf ]

Roby YA, Bushey MA, Cheng LE, Kulaga HM, Lee S-J, Reed RR. (2012) Zfp423/OAZ mutation reveals the importance of Olf/EBF transcription activity in olfactory neuronal maturation. Journal of Neuroscience 32, 13679–88a. [ link ]

Duan R, Jin P, Luo F, Zhang G, Anderson N, Chen EH. (2012) Group I PAKs function downstream of Rac to promote podosome invasion during myoblast fusion in vivo. Journal of Cell Biology 199(1):169-85. [ link ]

Baker RP, Urban S. (2012) Architectural and thermodynamic principles underlying intramembrane protease function. Nature Chemical Biology. 8, 759–768. [ link ]

Lee SJ, Huynh TV, Lee YS, Sebald SM, Wilcox-Adelman SA, Iwamori N, Lepper C, Matzuk MM, Fan CM. (2012) Role of satellite cells versus myofibers in muscle hypertrophy induced by inhibition of the myostatin/activin signaling pathway. Proceedings of the National Academy of Sciences USA 109, E2353-2360. [ link ]

Cooper CL, Hardy RR, Reth M, Desiderio S. (2012) Non-cell-autonomous hedgehog signaling promotes murine B lymphopoiesis from hematopoietic progenitors. Blood 7;119(23):5438-48. [ link ]

Holland AJ, Cleveland DW. (2012) Losing balance: the origin and impact of aneuploidy in cancer. EMBO Reports 13, 501-514. [ link ]

Ricard N, Ciais D, Levet S, Subileau M, Mallet C, Zimmers TA, Lee S-J, Bidart M, Feige J-J, Bailly S. (2012) BMP9 and BMP10 are critical for postnatal retinal vascular remodeling. Blood 119, 6162–6171. [ link ]

Holland AJ, Fachinetti D, Da Cruz S, Zhu Q, Vitre B, Lince-Faria M, Verma IM, Bettencourt-Dias M, Cleveland DW. (2012) Polo-like kinase 4 controls centriole duplication but does not directly regulate cytokinesis. Molecular Biology of the Cell 23, 1838-1845. [ link ]

Darby MM, Serebreni L, Pan X, Boeke JD, Corden JL. (2012) The S. cerevisiae Nrd1-Nab3 Transcription Termination Pathway Acts in Opposition to Ras Signaling and Mediates Response to Nutrient Depletion. Molecular and Cellular Biology 32:1762-75. [ link ]

Djuranovic S, Nahvi A, Green R. (2012) miRNA-mediated gene silencing by translational repression followed by mRNA deadenylation and decay. Science 336, 237-240. [ link ]

Jamonnak N, Creamer T, Darby M, Schaughency P, Wheelan S, Corden J. (2011) Yeast Nrd1, Nab3 and Sen1 transcriptome-wide binding maps suggest multiple roles in post-transcriptional RNA processing. RNA 17, 2011-2025. [ link ]

Strong MA, Vidal-Cardenas SL, Karim B, Yu H, Guo N, Greider CW. (2011) Phenotypes in mTERT+/- and mTERT-/- Mice are Due to Short Telomeres, Not Telomere-Independent Functions of TERT. Molecular and Cellular Biology 31: 2369-2379. [ link ]

Urban S, Dickey SW. (2011) The rhomboid protease family: a decade of progress on function and mechanism. Genome Biology 12, 231. [ link ]

Creamer TJ, Darby MM, Jamonnak N, Schaughency P, Hao H, Wheelan SJ, Corden JL. (2011) Transcriptome-wide binding sites for componenets of the Saccharomyces cerevisiae non-poly(A) termination pathway: Nrd1, Nab3 and Sen1. PLoS Genetics 7, e1002329. [ link ]

Griffin EE, Odde DJ, Seydoux G. (2011) Regulation of the MEX-5 gradient by a spatially segregated kinase/phosphatase cycle. Cell 146(6):955-68. [ link ]

Jin P, Duan R, Luo F, Zhang G, Hong N, Chen EH. (2011) Competition between Blown fuse and WASP for WIP binding regulates the dynamics of WASP-dependent actin polymerization in vivo. Developmental Cell 20:623-638. [ link ]

Zhang L, Reynolds TL, Shan X, Desiderio S. (2011) Coupling of V(D)J recombination to the cell cycle suppresses genomic instability and lymphoid tumorigenesis. Immunity 34: 163-174. [ link ]

Regot S, Macia J, Conde N, Furukawa K, Kjellén J, Peeters T, Hohmann S, de Nadal E, Posas F, Solé R. (2011) Distributed biological computation with multicellular engineered networks. Nature 469(7329):207-11. doi: 10.1038/nature09679. [ link ]

Chen EH. (2011) Invasive podosomes and myoblast fusion. Membrane Fusion (Elsevier, USA), pp. 235-258. [ link ]

Gallo CM, Wang JT, Motegi F, Seydoux G. (2010) Cytoplasmic partitioning of P granule components is not required to specify the germline in C. elegans. Science 330(6011):1685-9. [ link ]

Desiderio S. (2010) Temporal and spatial regulatory functions of the V(D)J recombinase. Seminars in Immunology 22:362-369. [ link ]

Sens KL, Zhang S, Jin P, Duan R, Zhang G, Luo F, Parachini L, Chen EH. (2010) An invasive podosome-like structure promotes fusion pore formation during myoblast fusion. Journal of Cell Biology 191, 1013-1027. [ link ]

Cai J, Zhang N, Zheng Y, de Wilde RF, Maitra A, and Pan D. (2010) The Hippo signaling pathway restricts the oncogenic potential of an intestinal regeneration program. Genes & Devopment, (24): 2383-2388. [ pdf ]

Zhang N, Bai H, David KK, Dong J, Zheng Y, Cai J, Giovannini M, Liu P, Anders AA, and Pan D. (2010) The Merlin/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammals. Devopmental Cell, (19): 27-38. [ pdf ]

Yu J, Zheng Y, Dong J, Klusza S, Deng W-M, and Pan D. (2010) Kibra functions as a tumor suppressor protein that regulates Hippo signaling in conjunction with Merlin and Expanded. Developmental Cell, 18: 288-99. [ pdf ]

Greider, C.W. (2010) Telomerase Discovery: The Excitement of Putting Together Pieces of the Puzzle (Nobel Lecture). Angew. Chem. Int. Ed. Engl. 49:7422-7439. [ pdf ]

Kim Y*, Holland AJ*, Lan W, Cleveland DW. (2010). Aurora kinases and protein phosphatase 1 mediate chromosome congression through regulation of CENP-E. Cell. 142, 444-455. [ link ]

Corden JL. (2010). Shining a new light on RNA-protein interactions. Chemistry & Biology. 17(4):316-318. [ link ]

Holland AJ, Lan W, Niessen S, Hoover H, Cleveland DW. (2010). Polo-like kinase 4 kinase activity limits centrosome overduplication by autoregulating its own stability. Journal of Cell Biology. 188, 191-198. [ link ]

Vidal-Cardenas SL, Greider CW. (2010). Comparing effects of mTR and mTERT deletion on gene express and DNA damage response: a critical examination of telomere length maintenance-independent roles of telomerase. Nucleic Acids Research. 38: 60-71. [ link ]

Armanios M, Alder JK, Parry EM, Karim B, Strong MA, Greider CW. (2009). Short telomeres are sufficient to cause the degenerative defects associated with aging. American Journal of Human Genetics. 85, 823-832. [ link ]

Urban S. (2009) Making the cut: central roles of intramembrane proteolysis in pathogenic microorganisms. Nature Reviews Microbiology 7, 411–423. [ link ]

Corden JL. (2008). Yeast Pol II start-site selection: the long and the short of it. EMBO Reports. 9:1084-1086. [ link ]

Wu S, Liu Y, Zheng Y, Dong J and Pan D. (2008) The TEAD/TEF family protein Scalloped mediates transcriptional output of the Hippo growth-regulatory pathway. Developmental Cell, 14, 388-98. [ pdf ]

Baxt LA, Baker RP, Singh U, Urban S. (2008) An Entamoeba histolytica rhomboid protease with atypical specificity cleaves a surface lectin involved in phagocytosis and immune evasion. Genes & Development 22, 1636–1646. [ link ]

Zhang S, Chen EH. (2008). Ultrastructural analysis of myoblast fusion in Drosophila. Methods in Molecular Biology. 475, 275–297. [ link ]

Corden JL. (2007). Transcription. Seven ups the code. Science. 318:1735-1736. [ link ]

Dong J, Feldman G, Huang J, Wu S, Zhang N, Comerford S A, Gayyed M F, Anders R A, Maitra A, and Pan, D. (2007) Elucidation of a universal size-control mechanism in Drosophila and mammals Cell 130, 1120-1133. [ pdf ]

Dong J, Feldman G, Huang J, Wu S, Zhang N, Comerford S A, Gayyed M F, Anders R A, Maitra A, and Pan D. (2007) Elucidation of a universal size-control mechanism in Drosophila and mammals. Cell (130), 1120-1133. [ pdf ]

Liu Y, Subrahmanyam R, Chakraborty T, Sen R, Desiderio S. (2007). A plant homeodomain in RAG-2 that binds hypermethylated lysine 4 of histone H3 is necessary for efficient antigen-receptor-gene rearrangement. Immunity. 27:561-71. [ link ]

Baker RP, Young K, Feng L, Shi Y, Urban S. (2007) Enzymatic analysis of a rhomboid intramembrane protease implicates transmembrane helix 5 as the lateral substrate gate. Proceedings of the National Academy of Sciences USA 104, 8257–8262. [ link ]

Kaur R, Ma B, Cormack BP. (2007). A family of glycosylphosphatidylinositol-linked asparyl proteases is required for virulence of Candida glabrata. Proceedings of the National Academy of Sciences USA. 104:7628-7633. [ link ]

Feldser D, Greider CW. (2007). Short telomeres limit tumor progression in vivo by inducing senescence. Cancer Cell. 11, 461-469. [ link ]

Kim S, Shilagardi K, Zhang S, Hong S, Sens K, Bo J, Gonzalez GA, Chen EH. (2007). A Critical Function for the Actin Cytoskeleton in Targeted Exocytosis of Prefusion Vesicles during Myoblast Fusion. Developmental Cell. 12, 571-86. [ link ]

Baker RP, Wijetilaka R, Urban S. (2006) Two Plasmodium rhomboid proteases preferentially cleave different adhesins implicated in all invasive stages of malaria. PLoS Pathogens 2, e113. [ link ]

Caraveo G, van Rossum DB, Patterson RL, Snyder SH, Desiderio S. (2006). Action of TFII-I outside the nucleus as an inhibitor of agonist-induced calcium entry. Science. 314:122-5. [ link ]

Hao LY, Armanios M, Strong MA, Karim B, Feldser DM, Huso D, Greider CW. (2005). Short Telomeres, even in the Presence of Telomerase, Limit Tissue Renewal Capacity. Cell. 123: 1121-1131. [ link ]

Huang J, Wu S, Barrera J, Matthews K, and Pan, D. (2005) The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila homologue of YAP. Cell 122, 421-434. [ pdf ]

Chen EH, Olson EN. (2005). Unveiling the mechanisms of cell-cell fusion. Science 308, 369-373. [ link ]

Brossier F, Jewett TJ, Sibley LD, Urban S. (2005) A spatially localized rhomboid protease cleaves cell surface adhesins essential for invasion by Toxoplasma. Proceedings of the National Academy of Sciences USA 102, 4146–4151. [ link ]

Urban S, Wolfe MS. (2005) Reconstitution of intramembrane proteolysis in vitro reveals that pure rhomboid is sufficient for catalysis and specificity. Proceedings of the National Academy of Sciences USA 102, 1883–1888. [ link ]

Castaño I, Pan S, Zupancic M, Hennequin C, Dujon B, Cormack BP. (2005). Telomere length control and transcriptional regulation of sub-telomeric adhesins in Candida glabrata. Molecular Microbiology. 55: 1246-1258. [ link ]

Domergue R, Castaño I, De Las Peñas A, Zupancic M, Lockatell V, Hebel JR, Johnson D, Cormack BP. (2005). Nicotinic acid limitation regulates silencing of Candida adhesins during UTI. Science. 308: 866-870 [ link ]

Frieman MB, Cormack BP. (2003). The omega-site sequence of glycosylphosphatidylinositol-anchored proteins in Saccharomyces cerevisiae can determine distribution between the membrane and the cell wall. Molecular Microbiology. 50: 883-896. [ link ]

Wu S, Huang J, Dong J, Pan, D. (2003) hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts. Cell (114), 445-456. [ pdf ]

Urban S, Freeman M. (2003) Substrate specificity of rhomboid intramembrane proteases is governed by helix-breaking residues in the substrate transmembrane domain. Molecular Cell 11, 1425–1434. [ link ]

IJpma A, Greider CW. (2003). Short telomeres induce a DNA damage response in S. cerevisiae. Molecular Biology of the Cell. 14: 987-1001. [ link ]

Urban S, Lee JR, Freeman M. (2002) A family of Rhomboid intramembrane proteases activates all Drosophila membrane-tethered EGF ligands. EMBO Journal 21, 4277–4286. [ link ]

Urban S, Lee JR, Freeman M. (2001) Drosophila rhomboid-1 defines a family of putative intramembrane serine proteases. Cell 107, 173–182. [ link ]

Hemann, M.T., Strong, M., Hao, L.-Y., and Greider, C.W. (2001) The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability. Cell 107: 66-77. [ pdf ]

Chen, J.-L., Blasco, M, and Greider, C.W. (2000) A Secondary structure of vertebrate telomerase RNA. Cell 100:503-514. [ pdf ]